Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations.
Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations.
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DOI：
10.1002/oby.21404
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Church TS
中科院分区：
文献类型：
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作者：
Swift DL;Johannsen NM;Lavie CJ;Earnest CP;Blair SN;Church TS
To determine response rates for clinically significant weight loss (CWL) following different aerobic exercise training amounts and if enhanced cardiometabolic adaptations are observed with CWL compared to modest weight loss (MWL) or neither. Participants (N=330) performed 6 months of aerobic training at 4kcals per kg per week (KKW), 8KKW or 12 KKW (50%, 100%, and 150% of recommended levels respectively). Weight loss was categorized as CWL (≥5%) or MWL (3.0% to 4.9%) or neither. The CWL response rate was greater in the 8KKW group (20.2%, CI: 13.0 to 27.5%) compared to 4KKW (10.3%, CI: 4.6 to 16.0%), but not compared to the 12KKW group (14.6%, CI: 7.6% to 21.6%). Reductions in HOMA-IR were observed in participants with CWL (−0.60, CI: −0.98 to −0.22) and with MWL (−0.48, CI:−0.87 to −0.10), but not those who achieved neither (−0.06, CI −0.22 to 0.10). No changes between groups were observed for cholesterol, fitness, or blood pressure. Low response rates for CWL were observed following training, even at levels above recommended levels. Achieving MWL with exercise may represent a reasonable initial weight loss target since the improvement in insulin resistance with MWL are similar to what is achieved with CWL.
