Expression of neuron-specific enolase in adult rat brain following status epilepticus.
Expression of neuron-specific enolase in adult rat brain following status epilepticus.
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癫痫持续状态后成年大鼠脑中神经元特异性烯醇化酶的表达。
DOI：
10.1006/exnr.1999.7147
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
DeGiorgio,CM
中科院分区：
文献类型：
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作者：
Schreiber,SS;Sun,N;Tocco,G;Baudry,M;DeGiorgio,CM
神经元特异性烯醇化酶（NSE），一种关键的糖酵解酶，在脑脊液或血清中的水平增加与癫痫持续状态的持续时间和结果相关。为了进一步了解海藻酸钠诱导的NSE蛋白升高的分子基础，我们研究了全身给予红藻氨酸后成年大鼠脑中NSE mRNA的表达。研究结果表明，在癫痫持续状态期间和之后，NSE基因表达没有变化或减少，这表明转录后机制是癫痫诱导的NSE蛋白增加的原因。
Increased levels of neuron-specific enolase (NSE), a key glycolytic enzyme, in either the cerebrospinal fluid or the serum is correlated with both the duration and the outcome of status epilepticus. To further understand the molecular basis of seizure-induced elevations in NSE protein, we investigated NSE mRNA expression in the adult rat brain following systemic administration of kainic acid. The findings demonstrated either no change or a decrease in NSE gene expression during, and following, status epilepticus, suggesting that posttranscriptional mechanisms are responsible for seizure-induced increases in NSE protein.