Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?
Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?
复制标题
DOI：
10.1016/j.ijid.2020.05.110
复制
发表时间：
2020-08-01
影响因子：
8.4
通讯作者：
Peyssonnaux, Carole
中科院分区：
文献类型：
--
作者：
Edeas, Marvin;Saleh, Jumana;Peyssonnaux, Carole
冠状病毒2（SARS-CoV-2）大流行正在各大洲恶性蔓延，死亡率迅速上升。目前COVID-19的管理是基于呼吸衰竭是死亡的主要原因这一前提。然而，越来越多的证据将重症COVID-19患者的加速发病机制与涉及细胞因子风暴的高度炎症状态联系起来。升高的炎症状态的几个组分被作为治疗靶点。炎症状态升高的另一个关键组成部分是高铁蛋白血症，据报道，这会导致患者死亡风险增加。尽管与死亡率密切相关，但尚不清楚COVID-19患者的高铁蛋白血症是否仅仅是疾病进展的全身性标志物，还是疾病发病机制的关键调节因子。在这里，我们讨论了高铁蛋白血症的可能作用的含义，以及在COVID-19发病机制中改变的铁稳态，以及在这方面的潜在治疗靶点。(c)2020作者（S）由爱思唯尔有限公司代表国际传染病学会出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the continents with rapidly increasing mortality rates. Current management of COVID-19 is based on the premise that respiratory failure is the leading cause of mortality. However, mounting evidence links accelerated pathogenesis in gravely ill COVID-19 patients to a hyper-inflammatory state involving a cytokine storm. Several components of the heightened inflammatory state were addressed as therapeutic targets. Another key component of the heightened inflammatory state is hyper-ferritinemia which reportedly identifies patients with increased mortality risk. In spite of its strong association with mortality, it is not yet clear if hyper-ferritinemia in COVID-19 patients is merely a systemic marker of disease progression, or a key modulator in disease pathogenesis. Here we address implications of a possible role for hyper-ferritinemia, and altered iron homeostasis in COVID-19 pathogenesis, and potential therapeutic targets in this regard. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).