Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor
Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor
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DOI：
10.1111/cup.12576
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发表时间：
2015-11-01
影响因子：
1.7
通讯作者：
Katoh, Ryohei
中科院分区：
文献类型：
--
作者：
Nakazawa, Tadao;Kondo, Tetsuo;Katoh, Ryohei
汗孔癌是一种罕见的恶性肿瘤与腺附属器分化。一名38岁的日本男子在接受检查前约20年注意到右侧腹股沟区有皮下肿块。放射学检查显示肿块大小为11 x 10 cm，位于皮下脂肪组织中。近来肿块迅速增大，骨科医师根据原发性软组织肿瘤的临床诊断进行了活检。切除标本的组织学检查也显示肿瘤没有累及皮肤。显微镜下，肿瘤主要由孔样细胞组成，部分鳞状细胞分化明显，伴有CEA和EMA免疫反应阳性的局灶性导管结构。肿瘤包含一个低级别的区域，包括孔样细胞和高级别的区域与鳞状分化。这种组织病理学异质性表明恶性转化从汗孔瘤。该患者在过去的20年中，肿瘤几乎相同的大小，这是在以前的报告中最长的。报告一例皮下汗孔癌。
Porocarcinoma is a rare malignancy with glandular adnexal differentiation. A 38-year-old Japanese man noticed a subcutaneous mass in right inguinal region about 20 years prior to being examined. Radiological examinations demonstrated the mass, 11 x 10 cm in size, was in the subcutaneous fat tissue. Recently, the mass grew rapidly, and it was biopsied by an orthopedist based on clinical diagnosis of primary soft tissue tumor. Histopathological examination of the resected specimens also revealed that the tumor lacked involvement to the skin. Microscopically, the tumor was mainly composed of poroid cells with partially obvious squamous differentiation, accompanied by focal ductal structures immunoreactive for CEA and EMA. The tumor contained a low-grade area consisting of poroid cells and high-grade area with squamous differentiation. This histopathological heterogeneity suggested malignant transformation from poroma. The patient had the tumor in almost same size over the period of 20 years, which is the longest in the previous reports. This unique case of subcutaneous porocarcinoma is reported.