CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus
CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus
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DOI：
10.1093/infdis/jiv139
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发表时间：
2015-09-15
影响因子：
6.4
通讯作者：
Ray, Stuart C.
中科院分区：
文献类型：
--
作者：
Bailey, Justin R.;Dowd, Kimberly A.;Ray, Stuart C.
背景人类免疫缺陷病毒（HIV）感染导致急性感染后丙型肝炎病毒（HCV）清除率降低，HCV病毒血症增加，并加速HCV相关纤维化的进展。HIV加速HCV进展的潜在机制知之甚少，但HIV诱导的抗-HCV体液免疫应答功能障碍可能起作用。方法：aEuro积分为了确定HIV合并感染对抗-HCV抗体应答的影响，我们测量了抗-HCV包膜结合抗体滴度，中和抗体（nAb）滴度，结果：在HIV感染前后，HCV感染者血清中HCV特异性结合抗体和nAb滴度显著降低，而在HIV感染前后，HCV感染者血清中HCV特异性结合抗体和nAb滴度显著降低。HIV感染后CD 4（+）T细胞计数< 350/mm（3）的受试者，以及CD 4（+）T细胞计数< 200/mm（3）的受试者也显示nAb宽度减少。CD 4（+）T细胞计数维持在千分之350/mm（3）的受试者抗体水平几乎没有下降。结论：HIV感染导致的CD 4（+）T细胞的整体消耗导致抗HCV包膜抗体应答的整体下降，包括结合抗体滴度、nAb滴度和nAb宽度。
Background. Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role.Methods.aEuro integral To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection.Results.aEuro integral A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4(+) T-cell counts < 350/mm(3) after HIV infection, and subjects with CD4(+) T-cell counts < 200/mm(3) also showed a reduction in nAb breadth. Subjects who maintained CD4(+) T-cell counts a parts per thousand yen350/mm(3) displayed little to no decline in antibody levels.Conclusions.aEuro integral Depletion of CD4(+) T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.