Slow oscillation circuit of the intergeniculate leaflet
Slow oscillation circuit of the intergeniculate leaflet
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DOI：
10.55782/ane-2004-1512
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发表时间：
2004-01-01
影响因子：
1.4
通讯作者：
Blasiak, T
中科院分区：
文献类型：
--
作者：
Lewandowski, MH;Blasiak, T
膝状体间叶的慢振荡回路似乎构成了哺乳动物生物钟神经机制的一种自然的基本节律。迄今为止进行的研究结果表明，光信息流从视网膜的神经节细胞，是必要的，其产生。另一方面，由于GABA能中间神经元的振荡活动，该回路得以维持，其中大多数中间神经元主要与神经肽Y和脑啡肽结合形成该结构。大脑的非特异性投射的活动，其终端存在于膝状体间小叶，调节小叶神经元的慢振荡回路，但不改变其振荡模式。我们的假设预测了膝状体间小叶神经元的振荡活动在促进神经肽和神经激素的分泌中的作用，这些神经肽和神经激素存在于构成哺乳动物生物钟机制的元件和与之相关的结构中，这构成了具有超昼夜节律的哺乳动物生物钟的中枢机制与具有昼夜节律的外周时钟之间的一种功能性连接。
The slow oscillation circuit of the intergeniculate leaflet seems to constitute a natural basic rhythm of the neuronal mechanism of mammalian biological clock. The results of studies conducted so far indicate that photic information flowing from ganglion cells of the retina, is necessary for its generation. On the other hand, this circuit is maintained thanks to the oscillatory activity of GABAergic interneurons, the majority of which build up this structure, mainly in combination with neuropeptide Y and enkephalins. The activity of non-specific projections of the brain, whose terminals are present in the intergeniculate leaflet, modulates the slow oscillation circuit of the leaflet neurons, without changing its oscillatory pattern, though. Our hypothesis predicts a role of the oscillatory activity of intergeniculate leaflet neurons in facilitation the secretion of neuropeptides and neurohormones present in the very elements making up the mechanism of mammalian biological clock and structures linked to it. This constitutes a kind of functional Junction between the central mechanism of mammalian biological clock with an ultradian rhythm and its peripheral clocks whose rhythm is circadian.