Introduction to the Symposium: Stress Phenotype: Linking Molecular, Cellular, and Physiological Stress Responses to Fitness
Introduction to the Symposium: Stress Phenotype: Linking Molecular, Cellular, and Physiological Stress Responses to Fitness
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研讨会简介：压力表型：将分子、细胞和生理压力反应与健身联系起来
DOI：
10.1093/icb/icz098
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发表时间：
2019
影响因子：
2.6
通讯作者：
Wada, Haruka
中科院分区：
文献类型：
--
作者：
Heidinger, Britt J.;Wada, Haruka
虽然大多数生物体对环境和社会压力源的反应是通过启动压力反应来增加适应性，但我们目前缺乏关于压力反应如何在生物组织的各个层面上整合的信息。有机生物学家和生理生态学家倾向于关注糖皮质激素应激反应如何在生态环境中变化以及与适应性相关的问题，而分子和细胞生物学家通常研究基本的潜在机制。然而，越来越清楚的是，全面了解压力反应的演变将需要跨层次分析的综合研究。这些信息对于预测选择将如何影响这种复杂表型在生物体水平上的表达，以及潜在机制的整合将如何影响对选择的进化反应至关重要。由于预计各种生物体在面对人为干扰和气候变化时将面临越来越大的压力，这方面的信息变得越来越紧迫。本次研讨会的总体目标是汇集研究人员，研究不同生物体组织水平的压力反应，以确定知识和新的研究方法，可用于推进该领域的重要差距。
Although most organisms respond to environmental and social stressors by initiating a stress response that is expected to increase fitness, we currently lack information about how the stress response is integrated across levels of biological organization. Organismal biologists and physiological ecologists have tended to focus on questions related to how the glucocorticoid stress response varies across ecological contexts and is related to fitness, whereas, molecular and cellular biologists have typically investigated the fundamental underlying mechanisms. However, it is becoming increasingly clear that a comprehensive understanding of the evolution of the stress response will require integrative studies that span levels of analyses. This information will be critical for predicting how selection will influence the expression of this complex phenotype at the organismal level, as well as how the integration of the underlying mechanisms will influence the evolutionary response to selection. As diverse organisms are expected to experience rising stress exposure in the face of anthropogenic disturbance and climate change, this information is becoming increasingly urgent. The overarching goals of this symposium were to bring together researchers that study the stress response across levels of organization in diverse organisms to identify important gaps in knowledge and novel research approaches that could be used to advance the field.