Abundant empty class II MHC molecules on the surface of immature dendritic cells
Abundant empty class II MHC molecules on the surface of immature dendritic cells
复制标题
DOI：
10.1073/pnas.96.26.15050
复制
发表时间：
1999-12-21
影响因子：
11.1
通讯作者：
Stern, LJ
中科院分区：
文献类型：
--
作者：
Santambrogio, L;Sato, AK;Stern, LJ
一种单克隆抗体的空构象的II类MHC分子的特异性揭示了存在丰富的空分子的表面上的脾脏和骨髓来源的树突状细胞（DC）之间的各种类型的抗原呈递细胞。空的II类MHC分子受发育调控，主要在未成熟DC上表达。它们可以直接从细胞外介质中捕获肽抗原，并将结合的肽呈递给抗原特异性T淋巴细胞。空细胞表面II类MHC蛋白结合肽并将其呈递给T细胞而无需细胞内加工的能力可以用于扩展抗原范围DC能够呈递的抗原，这与它们作为免疫系统中哨兵的作用一致。
A monoclonal antibody specific for the empty conformation of class II MHC molecules revealed the presence of abundant empty molecules on the surface of spleen- and bone marrow-derived dendritic cells (DC) among various types of antigen-presenting cells. The empty class II MHC molecules are developmentally regulated and expressed predominantly on immature DC. They can capture peptide antigens directly from the extracellular medium and present bound peptides to antigen-specific T lymphocytes, The ability of the empty cell-surface class II MHC proteins to bind peptides and present them to T cells without intracellular processing can serve to extend the spectrum of antigens able to be presented by DC, consistent with their role as sentinels in the immune system.