Parallel Thermal Analysis Technology Using an Infrared Camera for High-Throughput Evaluation of Active Pharmaceutical Ingredients: A Case Study of Melting Point Determination
Parallel Thermal Analysis Technology Using an Infrared Camera for High-Throughput Evaluation of Active Pharmaceutical Ingredients: A Case Study of Melting Point Determination
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使用红外相机的并行热分析技术对活性药物成分进行高通量评估：熔点测定案例研究
作者：
K. Kawakami
可以使用96孔板进行用于活性药物成分的物理表征的各种技术，包括X射线粉末衍射、双折射观察、拉曼光谱和高效液相色谱。重要表征项目中唯一的例外是热分析，这在许多情况下可能是一个限制性步骤，特别是在筛选晶体/盐形式时。在这项研究中，红外热像仪技术应用于药物化合物的热表征。模型化合物的熔融温度通常在5分钟内确定，并且所获得的熔融温度值与差示扫描量热法测量的熔融温度值一致。由于许多化合物可以同时研究在这种红外技术，它应该是有前途的高通量热分析在药物开发过程中。
Various techniques for physical characterization of active pharmaceutical ingredients, including X-ray powder diffraction, birefringence observation, Raman spectroscopy, and high-performance liquid chromatography, can be conducted using 96-well plates. The only exception among the important characterization items is the thermal analysis, which can be a limiting step in many cases, notably when screening the crystal/salt form. In this study, infrared thermal camera technology was applied for thermal characterization of pharmaceutical compounds. The melting temperature of model compounds was determined typically within 5 min, and the obtained melting temperature values agreed well with those from differential scanning calorimetry measurements. Since many compounds can be investigated simultaneously in this infrared technology, it should be promising for high-throughput thermal analysis in the pharmaceutical developmental process.