Cancer-associated fibroblasts and the tumor microenvironment in non-small cell lung cancer
Cancer-associated fibroblasts and the tumor microenvironment in non-small cell lung cancer
复制标题
DOI：
10.1080/14737140.2022.2019018
复制
发表时间：
2021-12
影响因子：
3.3
通讯作者：
J. Suzuki;M. Tsuboi;G. Ishii
中科院分区：
文献类型：
--
作者：
J. Suzuki;M. Tsuboi;G. Ishii
非小细胞肺癌（NSCLC）随着病情的发展预后明显较差，即使采用现代治疗方法，预后仍然令人不满意。癌症不仅由癌细胞组成，还包括由各种细胞类型组成的基质。癌症相关成纤维细胞（CAFs）是基质和相关肿瘤微环境（TME）的主要组成部分。特别是，CAFs是阐明癌症进展的生物学机制和新的治疗靶点的关键组成部分。本文概述了非小细胞肺癌CAFs形成的TME。聚焦于非小细胞肺癌的TME，我们讨论了CAFs参与癌症进展、耐药和靶向CAFs治疗发展的机制。在TME中，CAFs通过直接接触或旁分泌细胞因子信号与癌细胞相互作用，深刻地促进了肿瘤的进展。CAFs还与各种其他基质成分相互作用，建立促进肿瘤的免疫抑制微环境并重塑细胞外基质。此外，这些效应与耐药性密切相关。进一步阐明基质微环境，包括CAFs，可能对非小细胞肺癌的治疗至关重要。
ABSTRACT Introduction Non-small cell lung cancer (NSCLC) has a markedly poor prognosis as it progresses, and the prognosis is still unsatisfactory even with modern treatments. Cancer is composed of not only cancer cells, but also stroma consisting of various cell types. Cancer-associated fibroblasts (CAFs) are a major component of the stroma and the associated tumor microenvironment (TME). Particularly, CAFs are a critical component in elucidating the biological mechanisms of cancer progression and new therapeutic targets. This article outlines the TME formed by CAFs in NSCLC. Areas covered Focusing on the TME in NSCLC, we discuss the mechanisms by which CAFs are involved in cancer progression, drug resistance, and the development of therapies targeting CAFs. Expert opinion In the TME, CAFs profoundly contribute to tumor progression by interacting with cancer cells through direct contact or paracrine cytokine signaling. CAFs also interact with various other stromal components to establish a tumor-promoting immunosuppressive microenvironment and remodel the extracellular matrix. Furthermore, these effects are closely associated with drug resistance. Further elucidation of the stromal microenvironment, including CAFs, could prove to be crucial in the treatment of NSCLC.