Morphology of corneal nerves and corneal sensation in dry eye:: a preliminary study
Morphology of corneal nerves and corneal sensation in dry eye:: a preliminary study
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DOI：
10.1038/sj.eye.6701760
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发表时间：
2005-12-01
期刊：
影响因子：
3.9
通讯作者：
Elhan, AH
中科院分区：
文献类型：
--
作者：
Hosal, BM;Örnek, N;Elhan, AH
目的探讨干眼症患者的角膜敏感性及神经形态学改变，方法对16例（10例干燥综合征，6例非干燥综合征）32眼干眼症患者及10例（19眼）正常对照者进行角膜敏感性及神经形态学观察。用Cochet-Bonnet感觉计测量中央角膜的敏感性。通过体内共焦显微镜（ConfoScan 2.0，Fortune Technologies Srl，Vigonza（PD），意大利）研究角膜神经的形态。结果干眼症组角膜敏感度（5.6mm/grs/S）明显低于正常对照组（5.0mm/grs/S）（P < 0.01）;干眼角膜上皮下神经厚度（平均6.38 ± 1.18 μ m）较对照眼（平均5.72 ± 1.27 μ m）厚，但差异无统计学意义（P >= 0.05）。
Purpose To evaluate the corneal sensitivity and nerve morphology in dry eyes.Methods A total of 32 eyes of 16 patients (10 Sjogren's syndrome and six non-Sjogren's syndrome) and 19 eyes of 10 age-matched controls were studied. Sensitivity of the central cornea was measured by the Cochet-Bonnet aesthesiometer. The morphology of corneal nerves was studied by in vivo confocal microscopy (ConfoScan 2.0, Fortune Technologies Srl, Vigonza (PD), Italy). Sub-basal epithelial nerve plexus, subepithelial nerve plexus, and stromal nerves were localized and evaluated for the number of nerves, thickness, reflectivity, and tortuosity for each frame.Results The mean corneal sensitivity of dry eye patients (5.6 mm/grs/S) was found significantly lower than that of the control (5.0 mm/grs/S) group (P < 0.01). Although the subepithelial nerves were thicker in dry eyes (mean: 6.38 +/- 1.18 mu m) than control eyes (mean: 5.72 +/- 1.27 mu m), this difference was not significant (P >= 0.05).Conclusion Decreased corneal sensitivity is not associated with morphological changes of corneal nerves in dry eyes.