Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment.
Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment.
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衣原体获取营养物质：生活在细胞内隔室中的独特挑战。
DOI：
10.1016/j.mib.2009.11.002
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发表时间：
2010
影响因子：
5.4
通讯作者：
Valdivia,RaphaelH
中科院分区：
文献类型：
--
作者：
Saka,HectorAlex;Valdivia,RaphaelH
衣原体是专性细胞内病原体，在膜结合液泡（称为“包涵体”）内复制。从这个隔室中，细菌通过选择性地重定向运输囊泡和劫持细胞内细胞器来获取必需的营养物质。重新路由是通过多种机制实现的，包括蛋白水解介导的高尔基体断裂、Rab GTPases 和 SNARE 的募集以及细胞质细胞器易位到包涵体腔中。鉴于衣原体与真核细胞的共同进化，多种细胞途径的共同选择很可能是一种从宿主获取必需营养物质时提供冗余的策略，并有助于这些高度适应的病原体的成功。
The Chlamydiae are obligate intracellular pathogens that replicate within a membrane-bound vacuole, termed the ‘inclusion’. From this compartment, bacteria acquire essential nutrients by selectively redirecting transport vesicles and hijacking intracellular organelles. Rerouting is achieved by several mechanisms including proteolysis-mediated fragmentation of the Golgi apparatus, recruitment of Rab GTPases and SNAREs, and translocation of cytoplasmic organelles into the inclusion lumen. Given Chlamydiae's extended coevolution with eukaryotic cells, it is likely that co-option of multiple cellular pathways is a strategy to provide redundancy in the acquisition of essential nutrients from the host and has contributed to the success of these highly adapted pathogens.