Opposite effects of a D1 and a D2 agonist on oral movements in rats.
Opposite effects of a D1 and a D2 agonist on oral movements in rats.
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D1 和 D2 激动剂对大鼠口腔运动的相反作用。
DOI：
10.1016/0014-2999(87)90134-8
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发表时间：
1987
影响因子：
5
通讯作者：
Ellison,G
中科院分区：
文献类型：
--
作者：
Johansson,P;Levin,E;Gunne,L;Ellison,G
给药三剂D1激动剂（sk&f 38393）或D2激动剂（LY171555）中的一剂的大鼠的口腔运动通过闭路电视观察，并同时使用计算机视频分析系统记录，该系统测量大鼠口腔上下两个荧光点之间的距离。D1激动剂SK&F 38393诱导震颤性口腔运动、舌突的剂量依赖性增加，在最高剂量下，重复咀嚼运动增加。相反，D2激动剂LY171555在所有剂量水平下均产生抑制或口服活性。在最低剂量的测试中，这似乎反映了一种非特异性的活动减少，因为所有类别的行为都被抑制，以及所有电脑评分的运动幅度和缓慢、缓慢的运动都被记录下来。但高剂量的LY171555诱导了过度活跃和刻板重复的头部运动，而咀嚼运动、颤抖的口腔运动和舌头突出仍然减少。D1和D2多巴胺受体似乎对口腔运动有相反的影响。
Oral movements in rats administered one of three doses of either a D1 agonist (SK & F 38393) or a D2 agonist (LY171555) were observed via closed-circuit television and simultaneously recorded using a computerized video analysis system which measured the distance between two fluorescent dots painted above and below the rat's mouth. The D1 agonist SK&F 38393 induced a dose-dependent increase in tremorous oral movements, tongue protrusions, and, at the highest dose, increased repetitive chewing movements. Conversely, the D2 agonist LY171555 produced an inhibition or oral activity at all dose levels. At the lowest dose tested this appeared to reflect a non-specific decrease in activity, for there was an inhibition of all categories of behavior measured, as well as of all amplitudes of computer-scored movements and slow, sluggish movements were recorded. But higher doses of LY171555 induced hyperactivity and stereotyped, repetitive head movements whereas chewing movements, tremorous oral movements, and tongue protrusions were still decreased. D1 and D2 dopamine receptors appear to have opposite effects on oral movements.