A pilot study of compositional analysis of the breast and estimation of breast mammographic density using three-dimensional T1-weighted magnetic resonance imaging.
A pilot study of compositional analysis of the breast and estimation of breast mammographic density using three-dimensional T1-weighted magnetic resonance imaging.
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DOI：
10.1158/1055-9965.epi-07-2547
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发表时间：
2008-09
期刊：
影响因子：
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通讯作者：
Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
中科院分区：
文献类型：
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作者：
Khazen M;Warren RM;Boggis CR;Bryant EC;Reed S;Warsi I;Pointon LJ;Kwan-Lim GE;Thompson D;Eeles R;Easton D;Evans DG;Leach MO;Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
介绍了一种利用三维T1加权磁共振成像（MRI）估计乳腺百分比密度的方法和计算机工具，并与乳腺摄影百分比密度（XRM）进行了比较。获得伦理批准和知情同意。描述了一种评估MRI乳腺密度的方法，即在3D T1加权MR图像上含水组织所占体积百分比，并在一项试点研究中应用于138例受试者，这些受试者在MARIBS筛选研究期间接受MRI和XRM成像。为了进行比较，从匹配的XRM测量乳腺摄影密度百分比，作为使用21分评分视觉评分的密度与总投影面积的比率，并通过应用2D交互式程序（CANULUS）测量。比较MRI和XRM百分比方法，包括评估左右一致性和阅片者间一致性。MRI密度百分比与使用Cumulus估计的乳腺摄影密度百分比密切相关（r=0.78，p<0.0001）。与视觉评估的比较也显示出很强的相关性。与MRI体积评估相比，乳腺摄影方法高估密度接近2倍。MRI提供了对乳房中水基组织比例的直接3D测量。它与视觉和计算机化的乳腺X线摄影密度测量结果相关性很好。这种方法可以直接应用于通过乳房MRI进行乳腺癌筛查的女性，并有助于确定风险。
A method and computer-tool to estimate percentage MRI breast density using 3D T1-weighted Magnetic Resonance Imaging (MRI) is introduced, and compared with mammographic percentage density (XRM). Ethical approval and informed consent were obtained. A method to assess MRI breast density as percentage volume occupied by water-containing tissue on 3D T1-weighted MR images is described and applied in a pilot study to 138 subjects who were imaged by both MRI and XRM during the MARIBS screening study. For comparison, percentage mammographic density was measured from matching XRMs as a ratio of dense to total projection areas scored visually using a 21 point score and measured by applying a 2D interactive program (CUMULUS). The MRI and XRM percent methods were compared, including assessment of left-right and inter-reader consistency. Percent MRI density correlated strongly (r=0.78, p<0.0001) with percent mammographic density estimated using Cumulus. Comparison with visual assessment also showed a strong correlation. The mammographic methods overestimate density compared with MRI volumetric assessment by a factor approaching 2. MRI provides direct 3D measurement of the proportion of water based tissue in the breast. It correlates well with visual and computerised percent mammographic density measurements. This method may have direct application in women having breast cancer screening by breast MRI and may aid in determination of risk.