Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis
Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis
复制标题
DOI：
10.3945/ajcn.111.026393
复制
发表时间：
2012-05-01
影响因子：
7.1
通讯作者：
Peeters, Petra H. M.
中科院分区：
文献类型：
--
作者：
Braem, Marieke G. M.;Onland-Moret, N. Charlotte;Peeters, Petra H. M.
背景：2007年，世界癌症研究基金会的报告得出结论，咖啡和茶的消费对上皮性卵巢癌(EOC)风险的影响的证据有限且不一致。目的：在欧洲癌症与营养前瞻性调查(EPIC)中，我们旨在调查咖啡和茶的摄入是否与EOC的风险相关。设计：所有参与EPIC的女性(n=330,849)都参与了这项研究。咖啡和茶的消费数据是通过经过验证的食物频率问卷在基线上收集的。用COX比例风险模型估计HRS和95%的顺应性。此外，我们对2011年4月之前的所有前瞻性研究进行了最新的荟萃分析，比较了咖啡和茶的最高和最低消费类别，并使用剂量-反应随机效应元回归分析。结果：在11.7年的中位随访期间，1244名女性发生了EOC。未观察到EOC风险与饮用咖啡[HR：1.05(95%CI：0.75，1.46，与不摄入相比)]或喝茶[HR：1.07(95%CI：0.78，1.45与不摄入相比)]之间的关系。我们的荟萃分析结果证实了咖啡和茶的摄入量与卵巢癌风险之间缺乏联系。结论：流行病学研究没有提供足够的证据来支持咖啡和茶的摄入量与卵巢癌风险之间的关联。AM J Clin Nutr 2012；95：1172-81。
Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC).Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC.Design: All women participating in the EPIC (n = 330,849) were included in this study. Data on coffee and tea consumption were collected through validated food-frequency questionnaires at baseline. HRs and 95% CIs were estimated by using Cox proportional hazards models. Furthermore, we performed an updated meta-analysis of all previous prospective studies until April 2011 by comparing the highest and lowest coffee- and tea-consumption categories as well as by using dose-response random-effects meta-regression analyses.Results: During a median follow-up of 11.7 y, 1244 women developed EOC. No association was observed between the risk of EOC and coffee consumption [HR: 1.05 (95% CI: 0.75, 1.46) for the top quintile compared with no intake] or tea consumption [HR: 1.07 (95% Cl: 0.78, 1.45) for the top quintile compared with no intake]. This lack of association between coffee and tea intake and EOC risk was confirmed by the results of our meta-analysis.Conclusion: Epidemiologic studies do not provide sufficient evidence to support an association between coffee and tea consumption and risk of ovarian cancer. Am J Clin Nutr 2012;95:1172-81.