Dyspnoea at rest and at the end of different exercises in patients with near-fatal asthma
Dyspnoea at rest and at the end of different exercises in patients with near-fatal asthma
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DOI：
10.1183/09031936.04.00074703
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发表时间：
2004-08-01
影响因子：
24.3
通讯作者：
Milic-Emili, J
中科院分区：
文献类型：
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作者：
Barreiro, E;Gea, J;Milic-Emili, J
在有濒死性哮喘（NFA）病史的患者中观察到在阻力负荷下呼吸困难感知减弱。对这类患者在休息时以及各种运动终点时的呼吸困难感知进行了评估。对7名NFA患者和8名非NFA患者评估了呼吸功能和运动能力（6分钟步行距离、递增式功率自行车运动和吸气阈值负荷）。在休息时以及各种运动终点时测量呼吸困难（博格量表）。NFA患者休息时的呼吸困难明显较轻。尽管NFA组和非NFA组的运动耐量都有相似程度的降低，但前者在功率自行车运动峰值时的呼吸困难明显较轻（2.6±2对比6.1±3.8（博格量表；均值±标准差）），且前者主要（86%）因腿部不适而停止运动。在6分钟步行距离和吸气阈值负荷测试中也观察到类似趋势。运动峰值时的呼吸困难是NFA病情的最佳指标，当博格量表评分小于或等于6时，敏感度为100%，特异度为63%。濒死性哮喘患者在休息时以及各种运动终点时呼吸困难感知减弱。运动峰值时的呼吸困难是濒死性哮喘病情的最佳指标。
Blunted perception of dyspnoea under resistive loading has been observed in patients with a history of near-fatal asthma (NFA). The perception of dyspnoea at rest and at the end point of various exercises was assessed in such patients.Respiratory function and exercise capacity (6-min walking distance, incremental cycloergometry and inspiratory threshold loading) were assessed in seven NFA and eight non-NFA patients. Dyspnoea (Borg scale) was measured at rest and at the end point of the various exercises.Dyspnoea at rest was significantly lower in NFA patients. Although exercise tolerance was similarly reduced in both the NFA and non-NFA groups, dyspnoea at peak cycle exercise was significantly lower in the former (2.6+/-2 versus 6.1+/-3.8 (Borg scale; mean+/-SD)), who mainly (86%) stopped because of leg discomfort. A similar trend was observed in the 6-min walking distance and inspiratory threshold loading tests. Dyspnoea at peak exercise was the best indicator of the NFA condition, with a sensitivity of 100%, and specificity of 63% for a Borg scale score of less than or equal to6.Perception of dyspnoea is blunted in near-fatal asthma patients at both rest and the end point of various forms of exercise. Dyspnoea at peak exercise is the best indicator of the near-fatal asthma condition.