Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.
Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.
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DOI：
10.1016/j.cub.2015.07.037
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发表时间：
2015-08-31
期刊：
影响因子：
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通讯作者：
Ringstad N
中科院分区：
文献类型：
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作者：
Brandt JP;Ringstad N
Toll样受体（TLR）在许多动物物种的先天免疫中起关键作用。C. elegans - TOL-1 -是病原体回避行为所必需的，但它如何促进这种行为尚不清楚。我们表明，TOL-1信号是必需的化学感觉BAG神经元的病原体回避，在那里它调节基因表达，是必要的BAG化学感觉功能。遗传学研究表明，TOL-1与TLR信号传导的许多保守组分一起起作用。BAG神经元被二氧化碳（CO2）激活，我们发现这种方式是避免病原体所必需的。因此，TLR信号可以通过一种意想不到的机制介导宿主对微生物的反应：通过促进监视环境微生物代谢活动的化学感受神经元的发育和功能。
Toll-like receptors (TLRs) play critical roles in innate immunity in many animal species. The sole TLR of C. elegans - TOL-1 - is required for a pathogen avoidance behavior, yet how it promotes this behavior is unknown. We show that TOL-1 signaling is required in the chemosensory BAG neurons for pathogen avoidance, where it regulates gene expression and is necessary for BAG chemosensory function. Genetic studies revealed that TOL-1 acts together with many conserved components of TLR signaling. BAG neurons are activated by carbon dioxide (CO2) and we found that this modality is required for pathogen avoidance. TLR signaling can, therefore, mediate host responses to microbes through an unexpected mechanism: by promoting the development and function of chemosensory neurons that surveil the metabolic activity of environmental microbes.