Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping
Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping
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DOI：
10.1002/jbio.201200219
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发表时间：
2013-06-01
影响因子：
2.8
通讯作者：
Emelianov, Stanislav
中科院分区：
文献类型：
--
作者：
Chen, Yun-Sheng;Frey, Wolfgang;Emelianov, Stanislav
光声成像可用于指导和验证纳米粒子介导的光热疗法的治疗结果，通过其可视化纳米粒子造影剂的递送、成像活组织内的温度分布和确认组织凝固的能力。在这种图像引导的过程中，温度映射对于热剂量控制起着关键作用。因此，发展一种灵敏、准确的光声技术来定量测量热疗过程中的温度分布是非常必要的。在这项研究中，我们研究并证明，二氧化硅涂层的金纳米棒，可以提供一个多倍的光声温度映射的灵敏度相比，没有二氧化硅涂层的金纳米棒的改善，并作为一个纳米传感器，以准确和定量地可视化光热治疗过程中的温度分布。((c)2013 WILEY-VCH Verlag GmbH & Co. KGaA，魏因海姆）
Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle-mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image-guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica-coated gold nanorods, can provide a multi-fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)