Distortion-Free Imaging: A Double Encoding Method (DIADEM) Combined With Multiband Imaging for Rapid Distortion-Free High-Resolution Diffusion Imaging on a Compact 3T With High-Performance Gradients
Distortion-Free Imaging: A Double Encoding Method (DIADEM) Combined With Multiband Imaging for Rapid Distortion-Free High-Resolution Diffusion Imaging on a Compact 3T With High-Performance Gradients
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DOI：
10.1002/jmri.26792
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发表时间：
2020-01-01
影响因子：
4.4
通讯作者：
Bernstein, Matt A.
中科院分区：
文献类型：
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作者：
In, Myung-Ho;Tan, Ek Tsoon;Bernstein, Matt A.
背景：最近提出的基于DADEM的无失真高分辨率扩散成像方法具有很大的临床应用潜力。目的：通过评估新型紧凑型3T(C3T)的扩散定量测量的可靠性，并利用高性能梯度(80mT/m，700T/m/S)以及导航采集窗口缩小和同步多层(多波段)成像的序列优化，来研究基于Diadem的高分辨率扩散成像在新型紧凑型3T(C3T)上的临床可行性。对6例健康受试者和2例患者进行脑肿瘤扫描，比较扩散和解剖成像。场强/序列：3T；标准的单次激发回波平面成像(EPI)、多次激发头盔扩散成像和解剖(2D-FSE[快速自旋-回波]、2D-FLAIR[流体衰减-反转-恢复]和3D-MPRAGE[磁化准备的快速采集梯度回波])成像。评估：扫描时间缩短，定量扩散测量的可靠性，以及高分辨率扩散成像在健康对照组和脑瘤志愿者中的临床疗效。统计学检验：Bland-Altman分析。结果：高分辨率平面内(0.86 mm(2))分辨率，无失真，序列优化后，全脑弥散成像时间由10分钟缩短至5分钟。在Bland-Altman图中，所有模型的平均表观扩散系数(ADC)值都在95%的可信区间内。拟议的采集具有597.2赫兹的总非共振覆盖范围，比人脑预期的500赫兹带宽更宽，可以产生没有折叠伪影的无失真图像。因此，与EPI相比，该方法可以直接与解剖图像匹配，并能够更好地勾画肿瘤边界。数据结论：由于硬件和序列的改进，所提出的高分辨率扩散成像方法在C3T上临床上是可行的。
Background: Distortion-free, high-resolution diffusion imaging using DIADEM (Distortion-free Imaging: A Double Encoding Method), proposed recently, has great potential for clinical applications. However, it can suffer from prolonged scan times and its reliability for quantitative diffusion imaging has not been evaluated.Purpose: To investigate the clinical feasibility of DIADEM-based high-resolution diffusion imaging on a novel compact 3T (C3T) by evaluating the reliability of quantitative diffusion measurements and utilizing both the high-performance gradients (80 mT/m, 700 T/m/s) and the sequence optimization with the navigator acquisition window reduction and simultaneous multislice (multiband) imaging.Study Type: Prospective feasibility study.Phantom/Subjects: Diffusion quality control phantom scans to evaluate the reliability of quantitative diffusion measurements; 36 normal control scans for B-0-field mapping; six healthy and two patient subject scans with a brain tumor for comparisons of diffusion and anatomical imaging.Field Strength/Sequence: 3T; the standard single-shot echo-planar-imaging (EPI), multishot DIADEM diffusion, and anatomical (2D-FSE [fast-spin-echo], 2D-FLAIR [fluid-attenuated-inversion-recovery], and 3D-MPRAGE [magnetization prepared rapid acquisition gradient echo]) imaging.Assessment: The scan time reduction, the reliability of quantitative diffusion measurements, and the clinical efficacy for high-resolution diffusion imaging in healthy control and brain tumor volunteers.Statistical Test: Bland-Altman analysis.Results: The scan time for high in-plane (0.86 mm(2)) resolution, distortion-free, and whole brain diffusion imaging were reduced from 10 to 5 minutes with the sequence optimizations. All of the mean apparent diffusion coefficient (ADC) values in phantom were within the 95% confidence interval in the Bland-Altman plot. The proposed acquisition with a total off-resonance coverage of 597.2 Hz wider than the expected bandwidth of 500 Hz in human brain could yield a distortion-free image without foldover artifacts. Compared with EPI, therefore, this approach allowed direct image matching with the anatomical images and enabled improved delineation of the tumor boundaries.Data Conclusion: The proposed high-resolution diffusion imaging approach is clinically feasible on C3T due to a combination of hardware and sequence improvements.