Squamous cell carcinoma of the oral cavity: A clinicopathologic scoring system for evaluating risk of cervical lymph node metastasis
Squamous cell carcinoma of the oral cavity: A clinicopathologic scoring system for evaluating risk of cervical lymph node metastasis
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口腔鳞状细胞癌：评估颈部淋巴结转移风险的临床病理评分系统
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发表时间：
1995
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通讯作者：
Carmen Lopez Varela
中科院分区：
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作者：
C. N. Vila;C. Martínez;Ernesto Moro Rodríguez;Carmen Lopez Varela
本文对126例口腔鳞状细胞癌颈淋巴清扫术进行了研究。评估几项临床组织学参数及其与淋巴结转移的统计相关性。微血管侵犯(P<；6×10−7)、分化程度(P<；.0001)、T分类(P=.003)、肿瘤厚度(P=.005)、炎性浸润性(P=.011)、肿瘤间期(P=0.02)和神经周围扩散(P=0.04)与转移有关。我们设计了一个基于统计结果的评分系统，消除了对复杂数学公式的需要。我们测试了这一评分系统，评分在7~12分、13~16分、17~20分和21~30分的病例转移率分别为0%、20%、63.6%和86.3%。4组间转移率差异有非常显著意义(P=8×10−9)。总而言之，该评分系统是预测转移风险的可靠方法。
A series of 126 cases of squamous cell carcinoma of the oral cavity with neck dissection was studied. Several clinicohistologic parameters and statistical correlation with lymph node metastasis were evaluated. Statistical association with metastasis was found in the following factors: microvascular invasion (P < 6 × 10−7), grade of differentiation (P < .0001), T category (P = .003), tumor thickness (P = .005), inflammatory infiltration (P = .011), tumoral interphase (P = .02), and perineural spread (P = .04). We designed a scoring system based on statistical results that eliminates the need for complex mathematical formulas. We tested this scoring system; cases with scores ranging form 7 to 12, 13 to 16, 17 to 20, and 21 to 30 points showed metastasis in 0%, 20%, 63.6%, and 86.3% of cases, respectively. The differences between these four groups in relation to rate of metastasis were very significant (P = 8 × 10−9). In conclusion, this scoring system is a reliable method of predicting risk of metastasis.