Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios
Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios
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DOI：
10.1194/jlr.m006205
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发表时间：
2010-08-01
影响因子：
6.5
通讯作者：
Dallongeville, Jean
中科院分区：
文献类型：
--
作者：
Bokor, Szilvia;Dumont, Julie;Dallongeville, Jean
FADS 1-FADS 2基因簇[编码delta-5（D5 D）和delta-6（D 6D）去饱和酶]的遗传变异性与成人血浆长链PUFA（LCPUFA）和脂质水平相关。为了更好地理解这些关系，我们进一步描述了FADS 1-FADS 2遗传变异与青少年D5 D和D 6D活动之间的关联。在1，144名欧洲青少年（平均+/- SD年龄：14.7 +/- 1.4岁）中对13种单核苷酸多态性（SNP）进行基因分型。采用气相色谱法分析血清磷脂脂肪酸水平。D5 D和D 6D活性分别根据C20：4 n-6/C20：3 n-6和C20：3 n-6/C18：2n-6比率估计。9个SNPs的次要等位基因与较高的18：2n-6水平（1.9E-18
Genetic variability in the FADS1-FADS2 gene cluster [encoding delta-5 (D5D) and delta-6 (D6D) desaturases] has been associated with plasma long-chain PUFA (LCPUFA) and lipid levels in adults. To better understand these relationships, we further characterized the association between FADS1-FADS2 genetic variability and D5D and D6D activities in adolescents. Thirteen single nucleotide polymorphisms (SNPs) were genotyped in 1,144 European adolescents (mean +/- SD age: 14.7 +/- 1.4 y). Serum phospholipid fatty acid levels were analyzed using gas chromatography. D5D and D6D activities were estimated from the C20:4n-6/C20:3n-6 and C20:3n-6/C18:2n-6 ratios, respectively. Minor alleles of nine SNPs were associated with higher 18:2n-6 levels (1.9E-18