Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin a nephropathy
Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin a nephropathy
复制标题
DOI：
10.14670/hh-18-367
复制
发表时间：
2021-10-01
影响因子：
2
通讯作者：
Yamagata, Kunihiro
中科院分区：
文献类型：
--
作者：
Takahashi-Kobayashi, Mayumi;Usui, Joichi;Yamagata, Kunihiro
转录因子21（TCF 21）有助于哺乳动物肾发生，尤其是肾小球成熟。我们的前期研究提示其对肾小球损伤的影响，足细胞中TCF 21的表达与尿蛋白值呈正相关，也与尿TCF 21浓度呈正相关。我们现在专注于其对免疫球蛋白A肾病（IgAN）的临床过程的影响，因为IgAN患者构成了世界上最大的原发性慢性肾小球肾炎患者群体。20例IgAN患者根据肾小球TCF 21表达的免疫组化评分（IHS）分为IHS 1组（n=7）和IHS 2 +3组（n=13）。20例中16例随访2年。IHS 2 +3组尿蛋白量较重（p=0.03），尿TCF 21水平较高（p
Transcription factor 21 (TCF21) contributes to mammalian nephrogenesis, and especially to glomerular maturation. Our previous study suggested its influence on glomerular injury, showing that TCF21 expression in podocytes had a positive correlation with the urinary protein value and also with the urinary TCF21 concentration. We now focus on its influence on the clinical course of immunoglobulin A nephropathy (IgAN), as patients with IgAN constitute the largest population of individuals with primary chronic glomerulonephritis in the world. Twenty cases of IgAN were divided into two groups according to the immunohistological score (IHS) of glomerular TCF21 expression: group IHS1 (n=7) and group IHS2+3 (n=13). Sixteen of the 20 cases were followed up for 2 years. Group IHS2+3 had heavier urinary protein (p=0.03) and a greater urinary TCF21 level (p