ACTN3 R577X Polymorphism Is Associated With the Incidence and Severity of Injuries in Professional Football Players
ACTN3 R577X Polymorphism Is Associated With the Incidence and Severity of Injuries in Professional Football Players
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DOI：
10.1097/jsm.0000000000000487
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发表时间：
2019-01-01
影响因子：
2.7
通讯作者：
Calo, Carla M.
中科院分区：
文献类型：
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作者：
Massidda, Myosotis;Voisin, Sarah;Calo, Carla M.
目的：ACTN3 R577X基因变异导致全球18%的人缺乏α -肌动蛋白-3蛋白，并与运动表现和对偏心肌损伤的易感性增加有关。本研究的目的是调查ACTN3 R577X变异与职业足球运动员间接肌肉疾病/损伤之间的关系。设计：病例对照，基因型-表型关联研究。干预：研究招募了257名男性职业意大利足球运动员（来自意甲、Primavera、Allievi和giovvanissimi，年龄= 21.2±5.3岁）和265名非运动对照组。采用口腔拭子提取基因组DNA，采用PCR方法检测ACTN3 R577X基因型。从2009年至2014年期间的169名足球运动员的亚组中收集了结构-机械损伤和功能性肌肉障碍。主要结局指标：我们假设577XX基因型与更高的肌肉损伤易感性相关（与其他基因型相比）。结果：actn3xx （α -肌动蛋白-3缺乏症）球员的受伤发生率比ACTN3 RR球员高2.66(95%可信区间[CI]: 1.09-6.63, P = 0.02)，而RX和RR球员的受伤发生率相似。此外，actn3xx球员严重受伤的几率比RR球员高2.13 (95% CI: 1.25-3.74, P = 0.0054)，而RX球员严重受伤的几率比RR球员高1.63 （95% CI: 1.10-2.40, P = 0.015）。结论：ACTN3 R577X多态性与职业足球运动员肌肉损伤的发生率和严重程度有关；携带ACTN3 577XX基因型的运动员比携带RR基因型的运动员有更高的肌肉损伤几率。
Objective: The ACTN3 R577X gene variant results in the absence of the alpha-actinin-3 protein in similar to 18% of humans worldwide and has been associated with athletic performance and increased susceptibility to eccentric muscle damage. The aim of this study was to investigate the association between ACTN3 R577X variant and indirect muscle disorders/injuries in professional football players. Design: A case-control, genotype-phenotype association study. Intervention: Two hundred fifty-seven male professional Italian football players (from Serie A, Primavera, Allievi, and Giovanissimi; age = 21.2 +/- 5.3 years) and 265 nonathletic controls were recruited for the study. Genomic DNA was extracted using a buccal swab, and the ACTN3 R577X genotype was performed using a PCR method. Structural-mechanical injuries and functional muscle disorders were collected from a subgroup of 169 football players during the period of 2009 to 2014. Main Outcome Measure: We hypothesized that the 577XX genotype would be associated with higher predisposition to muscle injuries (compared with the other genotypes). Results: ACTN3 XX (alpha-actinin-3 deficiency) players had 2.66 higher odds for an injury incidence than their ACTN3 RR counterparts (95% confidence interval [CI]: 1.09-6.63, P = 0.02), whereas RX and RR players had similar injury incidence. Furthermore, ACTN3 XX players had 2.13 higher odds for having a severe injury compared with their RR counterparts (95% CI: 1.25-3.74, P = 0.0054), whereas RX individuals had 1.63 higher odds for having a severe injury compared with the RR players (95% CI: 1.10-2.40, P = 0.015). Conclusions: The ACTN3 R577X polymorphism is associated with the incidence and severity of muscle injuries in professional football players; players with the ACTN3 577XX genotype have higher odds of having muscle injuries than their RR counterparts.