A second nuclear protein is encoded by Epstein-Barr virus in latent infection.
A second nuclear protein is encoded by Epstein-Barr virus in latent infection.
复制标题
第二个核蛋白是由潜伏感染的 Epstein-Barr 病毒编码的。
DOI：
10.1126/science.2983420
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Kieff,E
中科院分区：
文献类型：
--
作者：
Hennessy,K;Kieff,E
Epstein-Barr病毒（EBV）基因组的一个区域在诱导细胞增殖中很重要，包括一个长开放阅读框。这个开放阅读框的一部分已经与aczgene融合并在大肠杆菌中表达。融合蛋白的抗血清在潜伏感染的生长转化淋巴细胞和体外培养的伯基特肿瘤细胞的细胞核中鉴定出一种蛋白质。这种核蛋白是由不同的病毒基因编码的，而不是编码先前描述的EBV核抗原EBNA的病毒基因。
A region of the Epstein-Barr virus (EBV) genome that is important in inducing cell proliferation includes a single long open reading frame. Part of this open reading frame has been fused to thelacZgene and expressed inEscherichia coli. Antisera to the fusion protein identify a protein in the nuclei of latently infected growth-transformed lymphocytes and in Burkitt tumor cells grown in vitro. This nuclear protein is encoded by a different virus gene than that which encodes the previously described EBV nuclear antigen, EBNA.