Are backyard characteristics relevant factors for the occurrence of human visceral leishmaniasis in Central-Western Brazil?
Are backyard characteristics relevant factors for the occurrence of human visceral leishmaniasis in Central-Western Brazil?
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DOI：
10.1093/trstmh/trz110
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发表时间：
2020-04-01
影响因子：
2.2
通讯作者：
Fernandes Fontes, Cor Jesus
中科院分区：
文献类型：
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作者：
Guimaraes Luz, Joao Gabriel;Carvalho, Amanda Gabriela;Fernandes Fontes, Cor Jesus
背景资料：本回顾性病例对照研究旨在调查与隆多诺波利斯市人体内脏利什曼病（VL）发生相关的因素，该地区是巴西中西部VL的高度流行区。方法：纳入了2011年至2016年隆多诺波利斯报告的所有VL病例。对于每种情况，招募了两个邻居和年龄匹配的对照，没有VL的过去和现在的历史和阴性rk 39免疫层析测试。通过访谈回顾性收集数据，评估社会经济方面，住房特征，后院特征，动物的存在和日常习惯。多因素条件Logistic回归分析，以确定与人类VL。结果：在研究期间，81 VL病例报告隆多诺波利斯，其中37（45.7%）被纳入本研究。还包括70个对照。与VL发生相关的变量是浴室和/或厨房与房屋其他部分分开的户外位置（OR 7.8; 95% CI 2.1至29.5），存在菜园（OR 5.3; 95%CI 1.3至21.2）和存在腐烂的水果（OR 10.7; 95%CI 2.0至52.1）在backyard.Conclusions：我们的研究结果表明后院的特点和VL之间的关联。这可能有助于指导全球对人畜共患VL的预防和控制措施。
Background: This retrospective case-control study aimed to investigate the factors associated with the occurrence of human visceral leishmaniasis (VL) in the municipality of Rondonopolis, which is a highly endemic area for VL in Central-Western Brazil.Methods: All VL cases reported in Rondonopolis from 2011 to 2016 were included. For each case, two neighborhood- and age-matched controls with the absence of past and present history of VL and negative rk39-based immunochromatographic test, were recruited. Data were retrospectively collected through interviews that assessed socioeconomic aspects, housing features, backyard characteristics, presence of animals and daily habits. A multivariate conditional logistic regression analysis was used to identify factors associated with human VL.Results: During the study period, 81 VL cases were reported in Rondonopolis, of which 37 (45.7%) were included in this study. Seventy controls were also included. The variables associated with VL occurrence were the outdoor location of a bathroom and/or kitchen separated from the rest of the house (OR 7.8; 95% CI 2.1 to 29.5), the presence of a vegetable garden (OR 5.3; 95% CI 1.3 to 21.2) and the presence of decaying fruits (OR 10.7; 95% CI 2.0 to 52.1) in the backyard.Conclusions: Our findings suggest an association between backyard characteristics and VL. This may be useful in guiding preventive and control measures against zoonotic VL worldwide.