Regulation of UDP glucuronosyltransferase genes.
Regulation of UDP glucuronosyltransferase genes.
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DOI：
10.2174/1389200033489442
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发表时间：
2003-05
影响因子：
2.3
通讯作者：
P. Mackenzie;P. A. Gregory;D. Gardner-Stephen;R. Lewinsky;B. Jorgensen;T. Nishiyama;W. Xie;A. Radomińska-Pandya
中科院分区：
文献类型：
--
作者：
P. Mackenzie;P. A. Gregory;D. Gardner-Stephen;R. Lewinsky;B. Jorgensen;T. Nishiyama;W. Xie;A. Radomińska-Pandya
细胞和组织的UDP葡萄糖醛酸基转移酶（UGT）含量是我们对主要通过与葡萄糖醛酸结合而消除的化学物质的反应的主要决定因素。肝脏和其他器官中UGT含量存在明显的个体间差异。导致这些差异的机制尚不清楚，但最有可能是UGT基因表达差异的结果。已经鉴定了几种参与UGT基因调控的转录因子。这些包括诸如肝细胞核因子1、CAAT-增强子结合蛋白、八聚体转录因子1和Pbx 2的因子，其似乎控制组织和器官中UGT的组成性水平。此外，UGT基因表达也通过结合和/或感测这些化学物质的存在的蛋白质的作用而被激素、药物和其他外来化学物质调节。这些蛋白质包括Ah受体，核受体超家族的成员，如CAR和PXR以及对应激反应的转录因子。
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs. The mechanisms that lead to these differences are unknown but are most likely the result of differential UGT gene expression. Several transcription factors involved in the regulation of UGT genes have been identified. These include factors such as Hepatocyte Nuclear Factor 1, CAAT-Enhancer Binding Protein, Octamer transcription Factor 1 and Pbx2, which appear to control the constitutive levels of UGTs in tissues and organs. In addition, UGT gene expression is also modulated by hormones, drugs and other foreign chemicals through the action of proteins that bind and/or sense the presence of these chemicals. These proteins include the Ah receptor, members of the nuclear receptor superfamily, such as CAR and PXR and transcription factors that respond to stress.