Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose
Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose
复制标题
DOI：
10.1016/j.jcct.2015.11.003
复制
发表时间：
2016-03-01
影响因子：
5.4
通讯作者：
Dey, Damini
中科院分区：
文献类型：
--
作者：
Ovrehus, Kristian Altern;Schuhbaeck, Annika;Dey, Damini
简介：冠状动脉计算机断层血管造影（CTA）可以将冠状动脉粥样硬化斑块成分分为钙化和非钙化。通过冠状动脉CTA定量测量冠状动脉斑块负荷可能在确定疾病进展或对药物治疗反应的系列研究中发挥作用。从低辐射剂量冠状动脉CTA中重复评估这种定量测量的可重复性以前没有评估过。目的：评价低辐射剂量冠状动脉CTA中半自动斑块分析算法对冠状动脉斑块体积评估的扫描间、观察者间和观察者内的可重复性。方法：对50例连续12天内接受两次128层双源CT扫描的患者，每次冠状动脉CTA平均辐射剂量为0.7 mSv，使用经过验证的软件（AutoPlaq）评估冠状动脉斑块的扫描间、观察者间和观察者内的可重复性。结果：扫描间、观察者间和观察者内对非钙化和钙化斑块体积的一致性非常好（Spearman rho 0.87-0.99）。扫描间非钙化斑块和钙化斑块体积的平均百分比差异分别为0.1% （p = 0.8）和1.9% (p = 0.19)，一致性上限分别为+/- 11%和+/- 48.5%；观察者之间和观察者内部的平均百分比差异分别为0.1% （p = 0.25）和0.3% (p = 0.001), 0.3% （p = 0.33）和0.4% (p = 0.59)，一致性界限分别为+/- 7%和+/- 32.9%,+/- 6.6%和+/- 32.1%。结论：在重复低辐射剂量冠状动脉CTA中，半自动斑块评估算法可实现冠状动脉斑块表征和定量测量的高重复性。(C) 2016年心血管计算机断层扫描学会。Elsevier Inc.出版。版权所有。
Introduction: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed.Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA.Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated.Results: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of +/- 11% and +/- 48.5%; per inter-and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of +/- 7% and +/- 32.9%, and +/- 6.6% and +/- 32.1%, respectively.Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.