New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases.

New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases.
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肾小球疾病中肾小球壁上皮细胞激活及其信号通路的新见解

DOI:
10.1155/2015/318935
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发表时间:
2015
影响因子:
--
通讯作者:
Zhang C
Zhang C
中科院分区:
生物学3区
文献类型:
--
作者:
Su H;Chen S;He FF;Wang YM;Bondzie P;Zhang C

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近年来,肾小球壁上皮细胞(佩奇)的研究越来越受到重视。佩奇的增殖是新月体肾小球肾炎的主要特征;此外,在过去的十年中,在几种类型的非炎症性肾小球肾病中发现了PEC的激活,例如局灶性节段性肾小球硬化症、糖尿病性肾小球病和膜性肾病。PEC激活的发病机制知之甚少;然而,一些研究微妙地阐明了这些过程中涉及的潜在机制和信号通路。本文就肾小球疾病中PEC活化的最新观察和概念以及PEC活化的最新信号通路作一综述。
The glomerular parietal epithelial cells (PECs) have aroused an increasing attention recently. The proliferation of PECs is the main feature of crescentic glomerulonephritis; besides that, in the past decade, PEC activation has been identified in several types of noninflammatory glomerulonephropathies, such as focal segmental glomerulosclerosis, diabetic glomerulopathy, and membranous nephropathy. The pathogenesis of PEC activation is poorly understood; however, a few studies delicately elucidate the potential mechanisms and signaling pathways implicated in these processes. In this review we will focus on the latest observations and concepts about PEC activation in glomerular diseases and the newest identified signaling pathways in PEC activation.
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