Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality
Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality
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DOI：
10.1097/01.ede.0000209454.41466.b7
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发表时间：
2006-05-01
期刊：
影响因子：
5.4
通讯作者：
Zureik, M
中科院分区：
文献类型：
--
作者：
Leone, N;Courbon, D;Zureik, M
背景：实验数据表明锌、铜和镁参与了癌症和动脉粥样硬化的发生。很少有纵向研究将这些矿物质与人群中的癌症或心血管疾病死亡率联系起来。方法：巴黎前瞻性研究2 （Paris Prospective Study 2）的数据来自4035名30-60岁的男性队列，用于评估血清锌、铜和镁与全因、癌症和心血管疾病死亡率之间的关系。基线时测定的血清矿物质值分为四分位数，分为低（第1四分位数，参照组）、中（第2 -3四分位数）和高（第4四分位数）。在18年的随访中，有339人死亡，其中176人死于癌症，56人死于心血管疾病。在控制各种潜在混杂因素后，使用Cox比例风险模型推断每个因素的相对风险（rr）。结果：与低铜值（第1四分位数）相比，高铜值（第4四分位数）与全因死亡的RR增加50% （RR = 1.5； 95%可信区间= 1.1-2.1）、癌症死亡率增加40%（1.4;0.9-2.2）和心血管死亡率增加30%（1.3;0.6-2.8）相关。高镁值与死亡率呈负相关，全因死亡（0.6;0.4-0.8）和心血管死亡（0.6;0.2-1.2）的RR降低40%，癌症死亡（0.5;0.3-0.8）的RR降低50%。此外，低锌和高铜组合的受试者的全因死亡率（2.6;1.4-5.0）和癌症死亡率（2.7;1.0-7.3）协同增加。同样，低锌和高镁的组合与全因死亡率（0.2;0.1-0.5）和癌症死亡率（0.2;0.1-0.8）的降低相关。结论：高血清铜、低血清镁、低血清锌伴高血清铜或低血清镁可增加中年男性的死亡风险。
Background: Experimental data suggest that zinc, copper, and magnesium are involved in carcinogenesis and atherogenesis. Few longitudinal studies have related these minerals to cancer or cardiovascular disease mortality in a population.Methods: Data from the Paris Prospective Study 2, a cohort of 4035 men age 30-60 years at baseline, were used to assess the association between serum zinc, copper, and magnesium and all-cause, cancer, and cardiovascular disease mortality. Serum mineral values measured at baseline were divided into quartiles and classified into low (1st quartile, referent group), medium (2nd-3rd quartiles), and high (4th quartile) values. During 18-year follow up, 339 deaths occurred, 176 as a result of cancer and 56 of cardiovascular origin. Relative risks (RRs) for each element were inferred using Cox's proportional hazard model after controlling for various potential confounders.Results: High copper values (4th quartile) were associated with a 50% increase in RRs for all-cause deaths (RR = 1.5; 95% confidence interval = 1.1-2.1), a 40% increase for cancer mortality (1.4; 0.9-2.2), and a 30% increase for cardiovascular mortality (1.3; 0.6-2.8) compared with low values (1st quartile). High magnesium values were negatively related to mortality with a 40% decrease in RR for all-cause (0.6; 0.4-0.8) and cardiovascular deaths (0.6; 0.2-1.2) and by 50% for cancer deaths (0.5; 0.3-0.8). Additionally, subjects with a combination of low zinc and high copper values had synergistically increased all-cause (2.6; 1.4-5.0) and cancer (2.7; 1.0-7.3) mortality risks. Similarly, combined low zinc and high magnesium values were associated with decreased all-cause (0.2; 0.1-0.5) and cancer (0.2; 0.1-0.8) mortality risks.Conclusions: High serum copper, low serum magnesium, and concomitance of low serum zinc with high serum copper or low serum magnesium contribute to an increased mortality risk in middle-aged men.