Erythromycin resistance in Borrelia burgdorferi.
Erythromycin resistance in Borrelia burgdorferi.
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伯氏疏螺旋体对红霉素的耐药性。
DOI：
10.1128/aac.46.11.3637-3640.2002
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发表时间：
2002
影响因子：
4.9
通讯作者：
Cabello,FelipeC
中科院分区：
文献类型：
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作者：
Terekhova,Darya;Sartakova,MarinaL;Wormser,GaryP;Schwartz,Ira;Cabello,FelipeC
伯氏疏螺旋体实验室菌株和临床分离株的药敏试验表明，它们对红霉素存在耐药性。对红霉素的最低抑菌浓度、最低杀菌浓度和细菌杀灭动力学的评估表明，这种耐药性通过预先接触抗生素而增加，依赖于接种量，可能是对耐药性增加的细菌细胞亚群进行选择的结果。
Susceptibility testing of laboratory strains and clinical isolates ofBorrelia burgdorferiindicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposure to the antibiotic, is dependent on inoculum size, and may be the result of selection of subpopulations of bacterial cells with increased resistance.