Estimating the rate of retinal ganglion cell loss to detect glaucoma progression An observational cohort study
Estimating the rate of retinal ganglion cell loss to detect glaucoma progression An observational cohort study
复制标题
DOI：
10.1097/md.0000000000004209
复制
发表时间：
2016-07-01
期刊：
影响因子：
1.6
通讯作者：
Tsujikawa, Akitaka
中科院分区：
文献类型：
--
作者：
Hirooka, Kazuyuki;Izumibata, Saeko;Tsujikawa, Akitaka
本研究旨在评估青光眼进展与通过结合青光眼患者的结构和功能测量获得的视网膜神经节细胞 (RGC) 估计值之间的关系。 在本观察性队列研究中，我们检查了 62 名青光眼患者的 116 只眼睛。使用 Cirrus 光学相干断层扫描 (OCT)，对所有眼睛进行至少 5 次连续视网膜神经纤维层 (RNFL) 测量。第一次和最后一次测量之间有 3 年的间隔。视野 (VF) 测试与 RNFL 成像在同一天使用汉弗莱视野分析仪的瑞典交互式阈值算法标准 30-2 程序进行。 RGC 计数的估计值是通过标准自动视野检查 (SAP) 和 OCT 获得的，然后使用加权平均值来确定每只眼睛的 RGC 数量的最终估计值。使用线性回归来计算 RGC 损失率，并使用趋势分析来评估连续 RNFL 厚度和 VF 进展。使用 OCT 的平均 RNFL 厚度参数导致在检查的 116 只眼睛中检测到 14 只眼睛的进展，而平均偏差斜率检测到 31 只眼睛的进展。当使用 RGC 损失率时，116 只眼睛中有 41 只眼睛检测到进展，平均 RGC 损失率为 -28,260 +/- 8110 个细胞/年。通过结合结构和功能测量来估计 RGC 损失率，与 OCT 或 SAP 相比，可以更好地检测青光眼进展。
This study aimed to evaluate the relationship between glaucoma progression and estimates of the retinal ganglion cells (RGCs) obtained by combining structural and functional measurements in patients with glaucoma.In the present observational cohort study, we examined 116 eyes of 62 glaucoma patients. Using Cirrus optical coherence tomography (OCT), a minimum of 5 serial retinal nerve fiber layer (RNFL) measurements were performed in all eyes. There was a 3-year separation between the first and last measurements. Visual field (VF) testing was performed on the same day as the RNFL imaging using the Swedish Interactive Threshold Algorithm Standard 30-2 program of the Humphrey Field Analyzer. Estimates of the RGC counts were obtained from standard automated perimetry (SAP) and OCT, with a weighted average then used to determine a final estimate of the number of RGCs for each eye. Linear regression was used to calculate the rate of the RGC loss, and trend analysis was used to evaluate both serial RNFL thicknesses and VF progression.Use of the average RNFL thickness parameter of OCT led to detection of progression in 14 of 116 eyes examined, whereas the mean deviation slope detected progression in 31 eyes. When the rates of RGC loss were used, progression was detected in 41 of the 116 eyes, with a mean rate of RGC loss of -28,260 +/- 8110cells/year.Estimation of the rate of RGC loss by combining structural and functional measurements resulted in better detection of glaucoma progression compared to either OCT or SAP.