MULTI-DYNEIN HYPOTHESIS
MULTI-DYNEIN HYPOTHESIS
复制标题
DOI：
10.1002/cm.970320212
复制
发表时间：
1995-01-01
影响因子：
--
通讯作者：
ASAI, DJ
中科院分区：
文献类型：
--
作者：
ASAI, DJ
轴突动力蛋白和细胞质动力蛋白已经进化出不同的策略来执行它们的任务。多动力蛋白假说准确地描述了高度特化的轴突同种异构体；每个异构体都由一个单独的基因编码，位于一个精确的位置，产生特定的力，这有助于整个繁殖弯曲的产生，并且在功能上不能与其他异构体互换。相比之下，细胞质动力蛋白，虽然携带许多不同的货物，似乎是一个异构体。一个有趣的问题是确定是否存在额外的细胞质动力蛋白，迄今为止尚未被描述，它们像轴突的对应物一样，被定制来执行特定的任务。
Axonemal dyneins and cytoplasmic dynein have evolved separate strategies to perform their tasks. The multi-dynein hypothesis accurately describes the highly specialized axonemal isoforms; each isoform is encoded by a separate gene, is located in a precise place, produces specific forces which contribute to the overall generation of propagated bending, and is not functionally interchangeable with other isoforms. In contrast, cytoplasmic dynein, although carrying many different cargoes, appears to be one isoform. An intriguing question is to determine whether there are additional cytoplasmic dyneins, heretofore uncharacterized, which, like their axonemal counterparts, are customized to perform specific tasks.