The hepatic stellate cell in the post-genomic era.
The hepatic stellate cell in the post-genomic era.
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DOI：
10.14670/hh-17.487
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发表时间：
2002-04
影响因子：
2
通讯作者：
H. Okuyama;Y. Shimahara;N. Kawada
中科院分区：
文献类型：
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作者：
H. Okuyama;Y. Shimahara;N. Kawada
2001年2月15日发表的人类基因组序列草案将提供有关人类遗传学、人类疾病、人类细胞生物学的大量信息。现在，医学科学家和细胞生物学家正将注意力转向利用基因微阵列来阐明基因的表达模式，并识别由基因编码的蛋白质的功能和表达模式。肝星状细胞是在肝脏病理生理中起多种作用的窦状细胞之一。星状细胞从维生素a储存表型向“肌成纤维细胞”表型的转变与慢性肝损伤期间肝纤维化密切相关。对星状细胞活化的分子机制的分析取得了很大进展，特别是在转化生长因子- β和血小板源性生长因子的细胞内信号转导，与细胞粘附相关的整合素信号转导，以及与细胞运动相关的Rho和病灶粘附激酶等领域。关于星状细胞活化的信息的积累将有助于建立一种新的治疗人类肝脏纤维化的策略。
The draft human genome sequence was published on February 15, 2001, which will provide a huge amount of information on human genetics, human disease, and human cell biology. Now, medical scientists and cell biologists are turning their attention to illustrating gene expression pattern using gene microarray and to identifying the functions and the expression patterns of proteins encoded by the genes. Hepatic stellate cell is one of the sinusoid-constituent cells that play multiple roles in the liver pathophysiology. Transformation of stellate cells from the vitamin A-storing phenotype to the "myofibroblastic" one closely correlates to hepatic fibrosis during chronic liver trauma. Analyses of the molecular mechanisms of stellate cell activation have made a great progress, in particular, in the field of intracellular signal transduction of transforming growth factor-beta and platelet-derived growth factor, integrin signaling related to cell-adhesion, and cell motility-associated Rho and focal-adhesion kinase. Accumulation of the information on the stellate cell activation would shed light on the establishment of a novel therapeutic strategy against fibrosis of human liver disease.