Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives.
Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives.
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DOI：
10.4103/2231-4040.143040
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发表时间：
2014-10
影响因子：
1.4
通讯作者：
Mishra P
中科院分区：
文献类型：
--
作者：
Pal D;Tripathi R;Pandey DD;Mishra P
杂环结构存在于不同类型的化合物中，这强烈地表明了结构对生理活性的深刻影响，并且在寻找有用的合成药物的努力中充分反映了对这一点的认识。为了寻找更好的药理活性药物，以及双取代1，3，4-恶二唑和1，3，4-噻二唑作为活性药效团的重要性，我们设计、合成、表征和评价了一系列不同取代的磺酰氨基1，3，4-恶二唑和1，3，4-噻二唑，分别用于其潜在的抗菌、镇痛和抗炎活性。在碱性介质中，通过氨基硫脲的分子内环化反应，合成了新的磺酰氨基1，3，4-恶二唑和1，3，4-噻二唑衍生物。反应通过芳族碳酰卤与氨基硫脲之间的反应进行。
The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The search for better pharmacological active drug and the importance of disubstituted 1,3,4-oxadiazole and 1,3,4-thiadiazole as active pharmacophores, prompted us to design, synthesize, characterize, and evaluate a series of differently substituted sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole for their potential antimicrobial, analgesic and antiinflammatory activity, respectively. New sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives were synthesized by intramolecular cyclization of thiosemicarbazide in alkaline medium. Reactions were carried out by the reaction between aromatic carbonyl halide and thiosemicarbazide.