Pseudomembranous Colitis: Not Always Caused by Clostridium difficile.
Pseudomembranous Colitis: Not Always Caused by Clostridium difficile.
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伪膜性结肠炎：并不总是由艰难梭菌引起。
DOI：
10.1155/2014/812704
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发表时间：
2014
影响因子：
0.8
通讯作者：
Ghazi,LeylaJ
中科院分区：
文献类型：
--
作者：
Tang,DerekM;Urrunaga,NathalieH;DeGroot,Hannah;vonRosenvinge,ErikC;Xie,Guofeng;Ghazi,LeylaJ
虽然典型的伪膜性结肠炎是由艰难梭菌引起的，但它也可由多种病因引起。据报道，某些药物、化学损伤、胶原性结肠炎、炎症性肠病、缺血和其他感染性病原体可导致粘膜损伤和随后的假膜形成。我们介绍了一名患有血管疾病的中年妇女的病例，她被错误诊断为难治性 C。由于假膜的存在而导致艰难梭菌感染。进一步的影像学检查、内窥镜检查和仔细的组织病理学检查显示，慢性缺血是导致她的伪膜性结肠炎和腹泻的原因。这个病例凸显了胃肠病学家考虑非 C 的必要性。诊断伪膜性结肠炎时的困难病原学。
Although classically pseudomembranous colitis is caused byClostridium difficile, it can result from several etiologies. Certain medications, chemical injury, collagenous colitis, inflammatory bowel disease, ischemia, and other infectious pathogens can reportedly cause mucosal injury and subsequent pseudomembrane formation. We present the case of a middle‐aged woman with vascular disease who was incorrectly diagnosed with refractoryC. difficileinfection due to the presence of pseudomembranes. Further imaging, endoscopy, and careful histopathology review revealed chronic ischemia as the cause of her pseudomembranous colitis and diarrhea. This case highlights the need for gastroenterologists to consider non‐C. difficileetiologies when diagnosing pseudomembranous colitis.