New anti-inflammatory withanolides from Physalis pubescens fruit
New anti-inflammatory withanolides from Physalis pubescens fruit
复制标题
来自毛酸浆果实的新型抗炎茄内酯
DOI：
10.1016/j.fitote.2020.104692
复制
发表时间：
2020-10-01
期刊：
影响因子：
3.4
通讯作者：
Li, Liya
中科院分区：
文献类型：
--
作者：
Wang, Guihua;Xu, Li;Li, Liya
毛酸浆是我国东北地区广泛栽培的一种药用植物。对毛白杨果实提取物的研究导致分离和鉴定了四种新的睡茄内酯，即，physapubescin J-M（1、2、4和5），以及四种已知的类似物（3、6-8）和十五种其他化合物。通过核磁共振、质谱、电子捕获检测器等波谱数据的分析，确定了化合物的结构。在分离物中，生叶紫青素J（1）含有不寻常的硫键，并且四种睡茄内酯（3、5、7和8）在LPS诱导的RAW 264. 7细胞中显示出潜在的抗氧化性。该研究支持毛白杨果实是一种有价值的睡茄内酯类化合物来源。进一步的研究，以探讨抗炎活性的分离睡茄内酯使用在体内模型是必要的
Physalis pubescens L. is a medicinal plant widely cultivated in northeast of China. Investigation on the extract of P. pubescens fruit led to the isolation and identification of four new withanolides, namely, physapubescins J-M (1, 2, 4 and 5), together with four known analogues (3, 6-8) and fifteen other compounds. Their structures were elucidated on the basis of comprehensive NMR, MS, and ECD spectroscopic data analysis. Among isolates, physapubescin J (1) contained an unusual sulphide linkage, and four withanolides (3, 5, 7 and 8) showed antiinflammatory potential in LPS-induced RAW264.7 cells. This study supports P. pubescens fruit could be a valuable source of withanolides. Further studies to investigate anti-inflammatory activities of isolated withanolides using in vivo models are warranted