A confirmation of sapovirus re-infection gastroenteritis cases with different genogroups and genetic shifts in the evolving sapovirus genotypes, 2002-2011
A confirmation of sapovirus re-infection gastroenteritis cases with different genogroups and genetic shifts in the evolving sapovirus genotypes, 2002-2011
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DOI：
10.1007/s00705-012-1387-7
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发表时间：
2012-10-01
影响因子：
2.7
通讯作者：
Katayama, Kazuhiko
中科院分区：
文献类型：
--
作者：
Harada, Seiya;Oka, Tomoichiro;Katayama, Kazuhiko
Sapovirus（SaV）是引起人类急性胃肠炎的重要病原体。人SaV在遗传上高度多样，并被分为多个基因组和基因型。目前，没有明确证据表明再次感染SaV导致肠胃炎病例。我们发现，两个人依次感染SaV的两个不同的基因组和胃肠炎后，每次感染，虽然在随后的情况下，SaV和诺如病毒检测。我们还发现了来自同一地理位置的胃肠炎门诊患者的SaV的遗传转变。我们的研究结果表明，保护性免疫可能至少是基因组特异性的SaV。
Sapovirus (SaV) is an important pathogen that causes acute gastroenteritis in humans. Human SaV is highly diverse genetically and is classified into multiple genogroups and genotypes. At present, there is no clear evidence for gastroenteritis cases caused by re-infection with SaV. We found that two individuals were sequentially infected with SaVs of two different genogroups and had gastroenteritis after each infection, although in one of the subsequent cases, both SaV and norovirus were detected. We also found a genetic shift in SaVs from gastroenteritis outpatients in the same geographical location. Our results suggest that protective immunity may be at least genogroup-specific for SaV.