BINDING OF RADIOACTIVELY LABELLED CONCANAVALIN-A AND WHEAT GERM AGGLUTININ TO NORMAL AND VIRUS-TRANSFORMED CELLS
BINDING OF RADIOACTIVELY LABELLED CONCANAVALIN-A AND WHEAT GERM AGGLUTININ TO NORMAL AND VIRUS-TRANSFORMED CELLS
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DOI：
10.1038/newbio232156a0
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
SAMBROOK, J
中科院分区：
文献类型：
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作者：
OZANNE, B;SAMBROOK, J
从植物中分离出来的各种物质会使动物细胞结块。这些凝集素中的几种1优先凝集自发转化或通过化学物质或病毒转化的细胞2 -7。这类凝集素中最著名的是从刀豆中分离出的伴刀豆球蛋白A（Con A）8和小麦胚芽凝集素4，它们似乎与细胞表面的碳水化合物基团结合。凝集素识别的WGA 4的决定簇可能是N-乙酰-D-葡萄糖胺，Con A6的决定簇可能是α-甲基-D-吡喃葡萄糖苷。
VARIOUS substances isolated from plants cause animal cells to clump. Several of these lectins1preferentially agglutinate cells which have been transformed spontaneously or by chemicals or viruses2–7. The best known lectins of this class are concanavalin A (Con A) isolated from jack beans8and wheat germ agglutinin4, which seem to bind to carbohydrate groups on the cell surface. The determinants recognized by the lectins seem to be N-acetyl-D-glucosamine for WGA4and probably α-methyl-D-glucopyranoside for Con A6.