Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos
Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos
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DOI：
10.1038/nature03488
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发表时间：
2005-05-12
期刊：
影响因子：
64.8
通讯作者：
Pourquié, O
中科院分区：
文献类型：
--
作者：
Vermot, J;Pourquié, O
大多数动物身体平面的一个显著特征是两侧对称。几乎没有人知道在发育过程中控制左右身体两侧对称排列的机制。在这里，我们报告说，在鸡胚胎中，阻止视黄酸（RA）的生产导致两个胚胎两侧之间的体节形成的deserminization，证明了一个缩短的左分割区域。该缺陷与分段时钟振荡的协调性丧失有关（1）。这种缺陷的偏侧化导致我们研究RA缺陷胚胎中体节发生与左右不对称机制之间的关系（2，3）。在缺乏RA的鸡（4，5）或小鼠（6）胚胎中恢复部位可逆转体节发育偏侧性缺陷。我们的数据表明，RA在缓冲左右机器的偏侧化影响方面是重要的，从而允许胚胎两侧发育的同步化。
A striking feature of the body plan of a majority of animals is bilateral symmetry. Almost nothing is known about the mechanisms controlling the symmetrical arrangement of the left and right body sides during development. Here we report that blocking the production of retinoic acid ( RA) in chicken embryos leads to a desynchronization of somite formation between the two embryonic sides, demonstrated by a shortened left segmented region. This defect is linked to a loss of coordination of the segmentation clock oscillations(1). The lateralization of this defect led us to investigate the relation between somitogenesis and the left - right asymmetry machinery(2,3) in RA-deficient embryos. Reversal of the situs in chick(4,5) or mouse(6) embryos lacking RA results in a reversal of the somitogenesis laterality defect. Our data indicate that RA is important in buffering the lateralizing influence of the left - right machinery, thus permitting synchronization of the development of the two embryonic sides.