URINARY-EXCRETION OF COCAINE, BENZOYLECGONINE, AND ECGONINE METHYL-ESTER IN HUMANS
URINARY-EXCRETION OF COCAINE, BENZOYLECGONINE, AND ECGONINE METHYL-ESTER IN HUMANS
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DOI：
10.1093/jat/12.6.301
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发表时间：
1988-11-01
影响因子：
2.5
通讯作者：
BELKNAP, S
中科院分区：
文献类型：
--
作者：
AMBRE, J;RUO, TI;BELKNAP, S
收集5名可卡因吸毒者30 h的全部尿液，测定可卡因（C）及其两种主要代谢产物苯甲酰芽子碱（BZ）和芽子碱甲酯（EME）的排泄动力学（受试者C、D、E、F和G）给予推注剂量，随后进行指数可卡因输注，（受试者C）、444（受试者D、E和F）和700 mg（受试者G）。血浆可卡因，尿可卡因，BZ，和EME通过气相色谱法测定，氮检测器。根据排泄率与时间的半对数图估计，EME和BZ的消除半衰期分别为3.1和4.5 h，与我们之前的报告一致。D、E和F的尿液回收率为剂量的27-41%，BZ为14-17%，EME为12-21%，可卡因为2%。受试者C排泄的EME非常少-比其他受试者的平均值低5-6倍，仅占剂量的3%。受试者G（接受最大剂量并达到3000 ng/mL的血浆水平）中的睾酮处置显示出非线性过程的一些特征。
The excretion kinetics of cocaine (C) and its two major metabolites, benzoylecgonine (BZ) and ecgonine methyl ester (EME), were determined by collecting all urine for 30 h from 5 cocaine users (subjects C, D, E, F, and G) given bolus doses followed by exponential cocaine infusions that delivered doses of 253 (subject C), 444 (subjects D, E, and F), and 700 mg (subject G). Plasma cocaine, urine cocaine, BZ, and EME were measured by gas chromatography, with a nitrogen detector. Elimination half-times for EME and BZ, estimated from semilog plots of excretion rates vs. time, averaged 3.1 and 4.5 h respectively, in agreement with our previous report. Urinary recovery in D, E, and F was 27-41% of the dose, with 14-17% as BZ, 12-21% as EME, and 2% as cocaine. Subject C excreted very little EME-5-6-fold less than the mean for the other subjects and amounting to only 3% of the dose. Cocaine disposition in subject G, who received the largest dose and attained plasma levels of 3000 ng/mL, showed some characteristics of a nonlinear process.