Lyme arthritis: Pathogenesis, clinical presentation, and management
Lyme arthritis: Pathogenesis, clinical presentation, and management
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DOI：
10.1016/j.idc.2007.12.014
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发表时间：
2008-06-01
影响因子：
4.4
通讯作者：
Kalish, Robert A.
中科院分区：
文献类型：
--
作者：
Puius, Yoram A.;Kalish, Robert A.
关节炎是莱姆病最突出的特征之一，莱姆病是由伯氏疏螺旋体引起的蜱传疾病。尽管莱姆关节炎的发病机制很复杂且仍在研究中，但其临床表现和自然病程已通过对未治疗和已治疗患者的长期观察而确定。这篇综述讨论了莱姆关节炎作为主要影响大关节的单关节或少关节复发/缓解性关节炎的临床表现，并描述了关节痛而不是关节炎的表现。讨论了诊断和治疗策略，并回顾了解决莱姆病治疗后可能出现的难治性莱姆关节炎和关节痛（有时作为所谓的莱姆病后综合征的组成部分）的方法。
Arthritis is one of the most prominent features of Lyme disease, the tick-borne illness caused by Borrelia burgdorferi. Although the pathogenesis of Lyme arthritis is complex and still under study, the clinical presentation and natural history have been established by long-term observation of untreated and treated patients. This review addresses the clinical presentation of Lyme arthritis as a mono- or oligoarticular relapsing/remitting arthritis primarily affecting the large joints and describes presentations in which arthralgias rather than arthritis are seen. Strategies for diagnosis and treatment are discussed, and methods are reviewed for addressing treatment-refractory Lyme arthritis and arthralgias that may occur after treatment of Lyme disease (sometimes as a component of what is known as the post-Lyme disease syndrome).