Clinical Application of Serologic Testing for Coronavirus Disease 2019 in Contemporary Cardiovascular Practice.
Clinical Application of Serologic Testing for Coronavirus Disease 2019 in Contemporary Cardiovascular Practice.
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DOI：
10.1161/jaha.120.019506
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发表时间：
2021-03
影响因子：
5.4
通讯作者：
deFilippi C
中科院分区：
文献类型：
--
作者：
Damluji AA;Christenson RH;deFilippi C
在心血管疾病患者中，随着2019年冠状病毒病大流行的持续演变，经常会遇到使用抗体或血清学检测的情况。抗体检测检测一种形式的获得性免疫反应病原抗原。一旦免疫系统将病毒抗原或蛋白质识别为外来物，就会启动体液免疫反应，通常在初次接触后5至10天内通过实验室检测检测到。虽然从公共卫生的角度来看，这些信息对于实施监测系统和限制传染性和传播率的措施至关重要，但在临床实践中对血清学检测的误解已经在医学界产生了许多混乱，因为一些人试图将这些策略应用于个体患者的治疗方案。在这篇小型综述中，我们研究了不同的基于血清学的检测策略，如何解释其结果，以及它们在人群水平上的公共卫生影响，这对于在繁忙的心血管实践中控制病毒在社区中的传播至关重要。此外，随着2019年冠状病毒病的疫苗接种和免疫治疗向整个社会开放，这一审查也将特别有帮助。
In patients with cardiovascular disease, the use of antibody or serological testing is frequently encountered as the coronavirus disease 2019 pandemic continues to evolve. Antibody testing detects one form of the acquired immunological response to a pathogenic antigen. Once the immune system recognizes a viral antigen or a protein as foreign, a humoral immune response is initiated, which is generally detected by laboratory testing in 5 to 10 days after the initial exposure. While this information is critical from a public health perspective to implement surveillance systems and measures to limit infectivity and transmission rate, the misinterpretation of serologic testing in clinical practice has generated much confusion in the medical community because some attempted to apply these strategies to individual patient's treatment schemes. In this mini‐review, we examine the different serologic‐based testing strategies, how to interpret their results, and their public health impact at the population level, which are critical to contain the transmission of the virus in the community within a busy cardiovascular practice. Further, this review will also be particularly helpful as vaccination and immune therapy for coronavirus disease 2019 become available to the society as a whole.