Deconstructing the neurobiology of cannabis use disorder.
Deconstructing the neurobiology of cannabis use disorder.
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DOI：
10.1038/s41593-020-0611-0
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发表时间：
2020-05
影响因子：
25
通讯作者：
Hurd, Yasmin L.
中科院分区：
文献类型：
--
作者：
Ferland, Jacqueline-Marie N.;Hurd, Yasmin L.
全世界对娱乐和医用大麻的态度和消费发生了巨大变化。大麻素受体介导大麻的作用，在已知介导与成瘾脆弱性相关的奖赏、认知、情绪调节和压力反应的神经过程的大脑区域中大量表达。尽管对大麻使用的潜在病理后果存在争议，但大麻使用障碍是一种在人群中患病率较高的临床诊断，通常起源于青春期和与精神共病、遗传和环境因素相关的弱势群体。来自人类和动物研究的综合信息开始扩大对与大麻使用障碍相关的神经生物学系统的认识，这些系统通常与其他物质使用障碍具有共同的神经特征，可以为预防和治疗策略提供信息。大麻使用的增加引起了人们对大麻使用障碍（CUD）及其神经生物学基础的极大关注。 Ferland 和 Hurd 在此讨论了与 CUD 发展及其神经生物学特征相关的危险因素。
There have been dramatic changes worldwide in the attitudes and consumption of recreational and medical cannabis. Cannabinoid receptors, which mediate the actions of cannabis, are abundantly expressed in brain regions known to mediate neural processes underlying reward, cognition, emotional regulation and stress responsivity relevant to addiction vulnerability. Despite debates regarding potential pathological consequences of cannabis use, cannabis use disorder is a clinical diagnosis with high prevalence in the population and that often has its genesis in adolescence and in vulnerable populations associated with psychiatric comorbidity, genetic and environmental factors. Integrated information from human and animal studies are beginning to expand insights regarding neurobiological systems associated with cannabis use disorder which often share common neural characteristics as other substance use disorders that could inform prevention and treatment strategies. The increasing use of cannabis has brought significant attention to cannabis use disorder (CUD) and its neurobiological underpinnings. Here Ferland and Hurd discuss risk factors related to the development of CUD its neurobiological characteristics.
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