Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells.
Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells.
复制标题
纠正仓鼠-人类杂交细胞中人类 19 号染色体的核苷酸切除修复突变。
DOI：
10.1007/bf01534738
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Siciliano,MJ
中科院分区：
文献类型：
--
作者：
Thompson,LH;Mooney,CL;Burkhart-Schultz,K;Carrano,AV;Siciliano,MJ
A UV-sensitive mutant line of CHO cells, UV20, was shown to be phenotypically corrected to resistance by fusion with human lymphocytes or fibroblasts. Only human chromosome 19 correlated with the DNA repair phenotype of resistant hybrid clones and their resistant or sensitive subclones. This study demonstrates the mapping of a human repair gene by direct selection of complementing hybrids in the presence of a DNA-damaging agent (mitomycin C).
