Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men
Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men
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DOI：
10.2337/dc07-0792
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发表时间：
2007-11-01
期刊：
影响因子：
16.2
通讯作者：
Otsuki, Makoto
中科院分区：
文献类型：
--
作者：
Shibata, Michihiko;Kihara, Yasuyuki;Otsuki, Makoto
目的：确定非酒精性脂肪性肝病与糖尿病发生风险之间的关系。研究设计与方法：我们对1997 - 2005年在日本一家公司工作的40岁男性员工进行了一项观察性队列研究。我们通过75克口服葡萄糖耐量试验排除了酒精摄入量>= 20克/天的工人和糖耐量受损的工人。其余3189名工人根据腹部超声检查结果分为脂肪肝组和非脂肪肝组。两组人都被跟踪观察糖尿病的发展情况。采用Cox比例风险分析确定风险比（HR）。采用巢式病例对照研究确定优势比（OR）。结果：参与者入组时的平均年龄为48.0岁，平均随访时间为4.0年。FL组的糖尿病发病率为2011 / 101,1101人/年（65例），而非FL组为452 / 100000人/年（44例）。糖尿病合并FL患者经年龄和bmi调整后的HR为5.5 （95% Cl 3.6 ~ 8.5, P < 0.001）。在嵌套病例对照分析中，调整年龄和BMI后的OR为4.6 （3.0-6.9,P < 0.001）。结论：非酒精性脂肪性肝病显著增加日本中年男性患糖尿病的风险。
OBJECTIVE - To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes.RESEARCH DESIGN AND METHODS- We conducted an observational cohort study in male workers >= 40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol intake >= 20 g/day and those with impaired glucose tolerance by a 75-g oral glucose tolerance test. The remaining 3,189 workers were classified into fatty liver (FL) and non-FL group based on the findings of abdominal ultrasonography. Both groups were followed for the development of diabetes. Hazard ratio (HR) was determined in Cox proportional hazard analysis. A nested case-control study was conducted to determine the odds ratio (OR).RESULTS - The average age of participants was 48.0 years at the entry, and the average follow-up period was 4.0 years. The incidence of diabetes in the FL group was 2,011 per 101,1101 person-years (65 cases), whereas 452 per 100,000 person-years (44 cases) in the non-FL group. The age- and BMI-adjusted HR of diabetes associated with FL was 5.5 (95% Cl 3.6-8.5, P < 0.001). In the nested case-control analysis, the OR adjusted for age and BMI was 4.6 (3.0-6.9, P < 0.001).CONCLUSIONS - Nonalcoholic fatty liver disease significantly increases the risk of diabetes in middle-aged Japanese men.