Total synthesis of apratoxin A
Total synthesis of apratoxin A
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DOI：
10.1021/ja036050w
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发表时间：
2003-07-23
影响因子：
15
通讯作者：
Forsyth, CJ
中科院分区：
文献类型：
--
作者：
Chen, JH;Forsyth, CJ
Apratoxin A是一种从蓝细菌Lyngbya spp中分离得到的环缩肽。全合成功能立体控制访问的新型聚酮和后期安装的敏感的2，4-二取代噻唑啉部分使用分子内施陶丁格还原/氮杂-维蒂希过程。
Apratoxin A, a cyclodepsipeptide isolated from cyanobacterialLyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process.