Variations in the individual thick lamellar properties within osteons by nanoindentation
Variations in the individual thick lamellar properties within osteons by nanoindentation
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DOI：
10.1016/s8756-3282(99)00163-5
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发表时间：
1999-09-01
期刊：
影响因子：
4.1
通讯作者：
Pharr, GM
中科院分区：
文献类型：
--
作者：
Rho, JY;Zioupos, P;Pharr, GM
纳米压痕法被用来检查在完成的次生骨单位内的个体厚板层属性的变化作为距离骨单位中心（哈佛管）的函数。一般来说，从骨单位中心向外，弹性模量和硬度均下降。由于某些骨单位可能具有与其他骨单位不同的总体趋势，因此还进行了协方差分析。总体分析对于弹性模量和硬度都是非常显著的。此外，骨单位数量作为一个因素是显著的，表明不同骨单位的整体厚板层性质存在一些差异，非配对t检验显示统计学显著差异（p = 0.0005和0.0004，从大多数内部两个骨层获得的厚层性质之间的差异（E = 20.8 +/-1.3GPa和H = 0.65 +/-0.06GPa）和来自最外两个骨层的那些（E = 18.8 +/-1.0GPa和H = 0.55 +/-0.05GPa）。在一般情况下，从接近骨单位的中心的板层属性大于那些从最外面的骨单位板。骨单位的机械性能也显著低于间质骨的机械性能（p < 0.0001）。最外骨单位板（E-1）（被认为是骨单位的软部分）和间质骨（E-2）的弹性模量的比率（E-1/E-2）约为0.7。这些结果可能对单个骨单位对骨生物力学的机械贡献具有重要意义。(C)1999年，Elsevier Science Inc. All rights reserved.
The nanoindentation method was used to examine variations in the individual thick lamellar properties within completed secondary osteons as a function of distance from the osteonal center (haversian canal). In general, there is a decline in both elastic modulus and hardness from the center of the osteon outward. Because some of the osteons may have a different general trend than others, an analysis of covariance was also carried out. The overall analysis was highly significant for both elastic modulus and hardness. Also, osteon number was significant as a factor, indicating that there was some difference in the overall thick lamellar properties of the different osteons, An unpaired t-test showed statistically significant differences (p = 0.0005 and 0.0004, respectively) between thick lamellar properties obtained from most of the inner two osteonal lamellae (E = 20.8 +/- 1.3 GPa and H = 0.65 +/- 0.06 GPa) and those from outermost two osteonal lamellae (E = 18.8 +/- 1.0 GPa and H = 0.55 +/- 0.05 GPa). In general, lamellar properties from near to the center of the osteon were greater than those from the outermost osteonal lamella. The mechanical properties of osteons are also significantly lower than those of the interstitial bone (p < 0.0001), The ratio (E-1/E-2) of the elastic moduli of the outermost osteonal lamella (E-1) (considered to be the soft part of the osteons) and that of interstitial bone (E-2) was approximately 0.7. These results may have important implications for the mechanical contribution of individual osteons to bone biomechanics. (C) 1999 by Elsevier Science Inc. All rights reserved.