Botulinum toxin to improve facial wound healing: A prospective, blinded, placebo-controlled study
Botulinum toxin to improve facial wound healing: A prospective, blinded, placebo-controlled study
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DOI：
10.4065/81.8.1023
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发表时间：
2006-08-01
影响因子：
8.9
通讯作者：
Sherris, David A.
中科院分区：
文献类型：
--
作者：
Gassner, Holger G.;Brissett, Anthony E.;Sherris, David A.
目的：测试肉毒杆菌毒素诱导的面部撕裂伤固定是否能促进伤口愈合并减少明显的疤痕。 患者和方法：在这项双盲、前瞻性、随机临床试验中，患者从 2002 年 2 月 1 日到 2004 年 1 月 1 日被随机分配，在伤口闭合后 24 小时内将肉毒杆菌毒素与安慰剂注射到伤口附近的肌肉组织中。由经验丰富的面部整形外科医生使用 10 厘米视觉模拟量表对标准化照片进行盲法评估作为主要结果衡量标准。 结果：本研究纳入了 31 名前额创伤性撕裂伤或接受选择性切除前额肿块的患者。肉毒杆菌毒素治疗组的总体中位视觉模拟量表评分为 8.9，而安慰剂组为 7.2 (P=.003)，表明实验固定疤痕的愈合增强并改善美观。 结论：肉毒杆菌毒素诱导的前额伤口固定可增强愈合，建议在选定的患者中使用，以改善疤痕的最终外观。
OBJECTIVE: To test whether botulinum toxin-induced Immobilization of facial lacerations enhances wound healing and results In less noticeable scars.PATIENTS AND METHODS: In this blinded, prospective, randomized clinical trial, patients were randomized from February 1, 2002, until January 1, 2004, to botulinum toxin vs placebo injection Into the musculature adjacent to the wound within 24 hours after wound closure. Blinded assessment of standardized photographs by experienced facial plastic surgeons using a 10-cm visual analog scale served as the main outcome measure.RESULTS: Thirty-one patients presenting with traumatic forehead lacerations or undergoing elective excisions of forehead masses were included In the study. The overall median visual analog scale score for the botulinum toxin-treated group was 8.9 compared with 7.2 for the placebo group (P=.003), Indicating enhanced healing and Improved cosmesis of the experimentally immobilized scars.CONCLUSIONS: Botulinum toxin-induced immobilization of forehead wounds enhances healing and is suggested for use in selected patients to improve the eventual appearance of the scar.