Consequences of acid catalysis in concurrent ring opening and halogenation of spiroketals.
Consequences of acid catalysis in concurrent ring opening and halogenation of spiroketals.
复制标题
酸催化同时发生螺酮缩环开环和卤化的后果。
DOI：
10.1021/ol991078r
复制
发表时间：
1999
期刊：
影响因子：
5.2
通讯作者：
Fuchs,PL
中科院分区：
文献类型：
--
作者：
LaCour,TG;Tong,Z;Fuchs,PL
刘易斯酸和/或布朗斯台德酸添加剂允许螺缩酮在显著降低的温度下开环和卤化，以提高的产率和纯度生产ω-碘代烯醇醚，其可以在远端亲电中心的存在下进行进一步反应，得到新的类固醇骨架。
Lewis and/or Bronsted acid additives permit ring opening and halogenation of spiroketals at substantially reduced temperatures to produce ω-iodo enol ethers in improved yield and purity, which can undergo further reaction in the presence of distal electrophilic centers to give new steroid skeletons.