Sex determination systems as the interface between male-killing bacteria and their hosts.
Sex determination systems as the interface between male-killing bacteria and their hosts.
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DOI：
10.1098/rspb.2021.2781
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发表时间：
2022-04-13
影响因子：
4.7
通讯作者：
Hurst, Gregory D. D.
中科院分区：
文献类型：
--
作者：
Hornett, Emily A.;Kageyama, Daisuke;Hurst, Gregory D. D.
节肢动物拥有一系列扭曲性别比例的自私因素，包括不同的母系遗传的内共生体，它们只杀死受感染的雄性。杀死雄性的可遗传微生物很常见，频率很高，但直到最近，对于宿主与微生物的相互作用，人们还知之甚少。此外，尽管杀死雄性应该会产生强烈的寄主抗性选择，但这方面的证据一直很少。微生物与宿主性别决定的接口对于理解死亡如何受性限制以及宿主如何进化来逃避雄性杀戮是不可或缺的。我们首先回顾了不同的内生菌用来诱导男性特异性死亡的机制的现有知识。然后，我们检查最近的证据，这些药物确实产生了对宿主核抑制分子的强烈选择。我们认为，根据我们对雄性杀死机制的理解，抑制通常涉及宿主性别决定途径的进化，因此宿主对杀死雄性的微生物的反应代表了节肢动物性别决定多样性的未知驱动因素。需要进一步的工作来确定负责男性杀戮抑制的基因和机制，这既将确定性别决定(或与抑制者进化相关的其他)系统的组成部分，也将使人们能够深入了解男性杀戮本身的机制。
Arthropods host a range of sex-ratio-distorting selfish elements, including diverse maternally inherited endosymbionts that solely kill infected males. Male-killing heritable microbes are common, reach high frequency, but until recently have been poorly understood in terms of the host–microbe interaction. Additionally, while male killing should generate strong selection for host resistance, evidence of this has been scant. The interface of the microbe with host sex determination is integral to the understanding of how death is sex limited and how hosts can evolve evasion of male killing. We first review current knowledge of the mechanisms diverse endosymbionts use to induce male-specific death. We then examine recent evidence that these agents do produce intense selection for host nuclear suppressor elements. We argue, from our understanding of male-killing mechanisms, that suppression will commonly involve evolution of the host sex determination pathways and that the host's response to male-killing microbes thus represents an unrecognized driver of the diversity of arthropod sex determination. Further work is required to identify the genes and mechanisms responsible for male-killing suppression, which will both determine the components of sex determination (or other) systems associated with suppressor evolution, and allow insight into the mechanism of male killing itself.
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影响因子：
3.7
作者：
Hayashi M;Watanabe M;Yukuhiro F;Nomura M;Kageyama D
通讯作者：
Kageyama D
影响因子：
9.8
作者：
Hornett EA;Charlat S;Duplouy AM;Davies N;Roderick GK;Wedell N;Hurst GD
通讯作者：
Hurst GD
影响因子：
16.6
作者：
Harumoto T;Anbutsu H;Lemaitre B;Fukatsu T
通讯作者：
Fukatsu T
影响因子：
3.8
作者：
Dyson, EA;Kamath, MK;Hurst, GDD
通讯作者：
Hurst, GDD
DOI：
10.1098/rspb.1975.0038
发表时间：
1975-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CLARKE, C;SHEPPARD, PM;SCALI, V
通讯作者：
SCALI, V